Abstract

ISEA, Raúl. B-cell epitopes mapping of dengue virus. INHRR [online]. 2013, vol.44, n.1, pp.25-29. ISSN 0798-0477.

Dengue virus has emerged as a major public health problem. An epitope-based approach to the development of vaccines, and for this reason, based on Immune Epitope Database database (IEDB), linear consensus B-cell epitopes were computationally generated and identified from dengue virus. Then, amino acids were grouped into blocks of eight amino acids per serotype through Nomad program. Each block was evaluated using BepiPred for determining antigenic prediction. 172 out of 1239 were obtained from IEDB.

Keywords : Computational Biology; epitope; vaccine; dengue; ExPASy.

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