Abstract

GONZALEZ ROZO, Natali; BRICENO, Yajaira  and  LACRUZ -RENGEL, María Angelina. Central Precocious Puberty and infantile Cerebral Palsy: Case Report. Arch Venez Puer Ped [online]. 2016, vol.79, n.2, pp.69-73. ISSN 0004-0649.

In central precocious puberty (cPP) there is a premature activation of the hypothalamic-pituitary-gonadal (hPg) axis that increases the production of sex steroids, which in turn stimulates growth rate, bone age advancement and the emergence of secondary sexual characteristics in both sexes. In the presence of cPP intracranial pathology must be ruled out, although with significant differences between boys and girls. The concept that cerebral palsy is associated with abnormal sexual maturation has been raised but has not been established. The intimate mechanism by which an intracranial activation insult occurs in early puberty is unknown, although it is speculated that on one hand there may be a mechanical factor that alters the inhibition of gonadotropin releasing hormone (gnrh) and secondly, depending on the type of injury there may be a predominance of one or other cell type, capable of secreting substances that trigger the secretion of gonadotropins.

Keywords : cerebral palsy; central precocious puberty.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )