Abstract

CANONICO S, Yeilis C; LAROCCA G, Nancy Elizabeth; MORENO, Dolores  and  DE SANCTIS, Juan Bautista. HLA y enfermedad pulmonar obstructiva crónica (EPOC). RFM [online]. 2008, vol.31, n.2, pp.111-115. ISSN 0798-0469.

Obstructive pulmonary disease is characterized by the progressive obstruction of air flow and it is partially reversible due to the destruction of the pulmonary parenchyma and inflammation of the air ways. The development of this inflammatory pathology depends on several factors including the major histocompatibility complex. Few studies have dealt with the possible role of major histocompatibility complex variations and obstructive pulmonary disease development and chronicity. Major histocompatibility complex class I and II genetic analysis was performed in 50 hybrid patients, with technique of amplification of specific primers (PCR-SSP) (Genovision®). As a comparison 108 controls were used. No significant differences were encountered in frequencies of class I and II patients with obstructive pulmonary disease and controls. No association was found in major histocompatibility complex polymorphism and obstructive pulmonary disease. Further studies should assess other genes for ascertain susceptibility to develop the disease.

Keywords : Obstructive pulmonary disease; Major histocompatibility complex.