<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0016-3503</journal-id>
<journal-title><![CDATA[Gen]]></journal-title>
<abbrev-journal-title><![CDATA[Gen]]></abbrev-journal-title>
<issn>0016-3503</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Venezolana de Gastroentereología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0016-35032021000100007</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Efectos del Levosulpiride sobre la motilidad vesicular en pacientes con diabetes mellitus tipo 2 complicada con neuropatía autonómica]]></article-title>
<article-title xml:lang="en"><![CDATA[Effects of Levosulpyride on vesicular motility in patients with diabetes mellitus type 2 complicated with autonomic neuropathy]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Louis Pérez]]></surname>
<given-names><![CDATA[Cesar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mejías Amatima]]></surname>
<given-names><![CDATA[Gabriel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Central de Venezuela Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Caracas ]]></addr-line>
<country>Venezuela</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Universitario de Caracas Servicio y Cátedra de Clínica Gastroenterológica ]]></institution>
<addr-line><![CDATA[Caracas ]]></addr-line>
<country>Venezuela</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2021</year>
</pub-date>
<volume>75</volume>
<numero>1</numero>
<fpage>7</fpage>
<lpage>12</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_arttext&amp;pid=S0016-35032021000100007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_abstract&amp;pid=S0016-35032021000100007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_pdf&amp;pid=S0016-35032021000100007&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Objetivo: determinar los efectos de levosulpiride sobre la motilidad vesicular en pacientes con diabetes mellitus tipo 2 con neuropatía autonómica.  Métodos: estudio descriptivo, prospectivo, transversal. se determinó volumen vesicular en ayuna, postprandial, residual y fracción de eyección a 16 pacientes, pre y post-administración de levosulpiride.  Resultados: el volumen vesicular basal fue 43,39cm3. posterior a la administración de levosulpiride se observó disminución significativa del volumen vesicular los 18 minutos (39,01cm3), 24 minutos (32,28cm3) y 30 minutos (22,86cm3). se determinó volumen residual (20,52cm3) y fracción de eyección (53,50%).  Conclusiones: la administración de levosulpiride produjo disminución significativa del volumen vesicular postprandial a los 18, 24 y 30 minutos, así como, aumento de la fracción de eyección vesicular, por tanto, mejoró la motilidad vesicular.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Summary:  Objetive: To determine the effects of levosulpiride on vesicular motility in patients with type 2 diabetes mellitus with autonomic neuropathy.  Methods: descriptive, prospective, transversal study. Vesicular volume at fasting, postprandial, residual and ejection fraction were determined in 16 patients, pre and post-administration of levosulpiride.  Results: The basal vesicular volume was 43.39 cm3. After the administration of levosulpiride, a significant decrease in vesicular volume was observed at 18 minutes (39.01 cm3), 24 minutes (32.28 cm3) and 30 minutes (22.86 cm3). The residual volume (20.52 cm3) and the ejection fraction (53.50%) were determined.  Conclusions: The administration of levosulpiride resulted in a significant decrease in postprandial vesicular volume at 18, 24 and 30 minutes, as well as an increase in the fraction of vesicular ejection, therefore, improved vesicular motility.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[diabetes mellitus]]></kwd>
<kwd lng="es"><![CDATA[neuropatía autonómica]]></kwd>
<kwd lng="es"><![CDATA[motilidad vesicular]]></kwd>
<kwd lng="es"><![CDATA[levosulpiride]]></kwd>
<kwd lng="en"><![CDATA[diabetes mellitus]]></kwd>
<kwd lng="en"><![CDATA[autonomic neuropathy]]></kwd>
<kwd lng="en"><![CDATA[vesicular motility]]></kwd>
<kwd lng="en"><![CDATA[levosulpiride]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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