<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0016-3503</journal-id>
<journal-title><![CDATA[Gen]]></journal-title>
<abbrev-journal-title><![CDATA[Gen]]></abbrev-journal-title>
<issn>0016-3503</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Venezolana de Gastroentereología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0016-35032025000200095</article-id>
<article-id pub-id-type="doi">10.61155/gen.v79i2.740</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Eje Cerebro-Intestino. Estrés, Microbiota y su impacto en la Salud Digestiva y Sistémica]]></article-title>
<article-title xml:lang="en"><![CDATA[The Brain-Gut Axis, Stress, and Microbiota: Their Impact on Digestive and Systemic Health]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Luzardo-Zschaeck]]></surname>
<given-names><![CDATA[Lesbia I]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Central de Venezuela Escuela de Medicina Luis Razetti ]]></institution>
<addr-line><![CDATA[Caracas ]]></addr-line>
<country>Venezuela</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<volume>79</volume>
<numero>2</numero>
<fpage>95</fpage>
<lpage>102</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_arttext&amp;pid=S0016-35032025000200095&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_abstract&amp;pid=S0016-35032025000200095&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_pdf&amp;pid=S0016-35032025000200095&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El estrés crónico tiene un impacto profundo en el cuerpo, afectando diversos sistemas, incluyendo el inmunológico. El eje hipotálamo pituitario-suprarrenal (HPA) regula la respuesta al estrés, liberando cortisol y adrenalina que, si son elevados durante períodos prolongados, pueden desencadenar enfermedades. La doctora Candice Pert descubrió que los neuro-péptidos, son moléculas que conectan el cerebro con el cuerpo, desempeñan un papel crucial en cómo las emociones influyen en la salud. Las emociones reprimidas, como la tristeza, rabia y miedo, alteran esta red molecular, debilitando el sistema inmunológico y favoreciendo la inflamación crónica, un factor importante en el cáncer. Además, estudios del Dr. Herbert Benson muestran cómo las &#8220;pérdidas&#8221; emocionales elevan el estrés y aumentan el riesgo de enfermedad. Las terapias como la psicoterapia, la musicoterapia y la hidroterapia pueden ser útiles en la sanación emocional y física. La salud intestinal es fundamental para el bienestar general, como lo señalaba Hipócrates. El microbiota, compuesta por bacterias, hongos, virus y parásitos, actúa como un órgano vital que influye en el sistema inmunológico, la producción de hormonas y neurotransmisores, y el metabolismo. Mantener un equilibrio entre los microbios intestinales es esencial para prevenir enfermedades, incluidas las crónicas. Una disbiosis, o desequilibrio del microbiota, puede generar inflamación crónica, afectando sistemas vitales y propiciando enfermedades autoinmunes, diabetes, enfermedades cardiovasculares y Cáncer. Una dieta basada en alimentos derivados de las plantas, ricos en fibra es esencial para la salud intestinal y la función del microbiota. Las fibras solubles (prebióticos) alimentan a las bacterias beneficiosas (firmicutes, bacteriodetes y otras) y el resultado de su trabajo son los post-bióticos como los butiratos, ácidos grasos de cadena corta, fundamentales para la salud del colon y el cerebro. Estos compuestos no solo nutren las células intestinales, sino que también refuerzan la barrera intestinal, previenen la pérdida de memoria y ayudan a mantener un peso corporal saludable. Otros ayudantes para la salud del intestino son los alimentos fermentados, como el yogurt, kefir, y kimchi, proporcionan probióticos que apoyan la diversidad bacteriana intestinal. El Dr. Will Bulsiewicz enfatiza que la fibra es el &#8220;corazón&#8221; de la salud intestinal, ayudando a prevenir enfermedades inflamatorias y crónicas al mantener un equilibrio entre los diferentes tipos de bacterias intestinales. Además, la conexión entre el intestino y el cerebro resalta la importancia de una alimentación adecuada para mejorar el estado de ánimo, reducir la ansiedad y mantener la salud mental y física. En síntesis, la salud es el resultado de un equilibrio entre el cuerpo, la mente y la alimentación. Mantener un microbiota intestinal saludable, gestionar el estrés y consumir una dieta rica en fibra y probióticos son fundamentales para prevenir y tratar enfermedades, incluyendo el cáncer. Las fuerzas naturales, como el sueño, la actividad física, las terapias emocionales y el factor fe complementan estos esfuerzos y permiten una sanación integral.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Chronic stress profoundly affects the body, particularly the immune system. The hypothalamic-pituitary-adrenal (HPA) axis regulates stress by releasing cortisol and adrenaline, which, when elevated long-term, contribute to disease. Dr. Candice Pert discovered that neuropeptides, which link the brain and body, mediate how emotions influence health. Repressed emotions-such as sadness, anger, and fear-disrupt this network, weakening immunity and promoting chronic inflammation, a key factor in cancer. Similarly, Dr. Herbert Benson's research highlights how emotional losses heighten stress and increase disease risk. Therapies like psychotherapy, music therapy, and hydrotherapy support both emotional and physical healing. Gut health is fundamental to overall well being, as Hippocrates noted. The microbiota-comprising bacteria, fungi, viruses, and parasites-acts as a vital organ influencing immunity, hormone production, neurotransmitters, and metabolism. A balanced microbiome is essential for preventing chronic diseases, while dysbiosis can lead to inflammation, autoimmune disorders, diabetes, cardiovascular disease, and cancer. A fiber-rich, plant-based diet is key to microbiota health. Soluble fiber (prebiotics) nourishes beneficial bacteria (Firmicutes, Bacteroidetes, and others), producing postbiotics like short-chain fatty acids (SCFAs), which support colon and brain health, strengthen the gut barrier, prevent memory loss, and regulate body weight. Fermented foods such as yogurt, kefir, and kimchi provide probiotics that enhance microbial diversity. Dr. Will Bulsiewicz emphasizes that fiber is the "heart" of gut health, balancing gut bacteria and preventing inflammation-related diseases. The gut-brain connection further underscores the importance of nutrition in improving mood, reducing anxiety, and maintaining overall health.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Microbiota]]></kwd>
<kwd lng="es"><![CDATA[Disbiosis]]></kwd>
<kwd lng="es"><![CDATA[Neuropéptidos]]></kwd>
<kwd lng="es"><![CDATA[Estrés]]></kwd>
<kwd lng="en"><![CDATA[Microbiota]]></kwd>
<kwd lng="en"><![CDATA[Dysbiosis]]></kwd>
<kwd lng="en"><![CDATA[Neuropeptides]]></kwd>
<kwd lng="en"><![CDATA[Stress]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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