<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0048-7732</journal-id>
<journal-title><![CDATA[Revista de Obstetricia y Ginecología de Venezuela]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Obstet Ginecol Venez]]></abbrev-journal-title>
<issn>0048-7732</issn>
<publisher>
<publisher-name><![CDATA[Sociedad de Obstetricia y Ginecología de Venezuela]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0048-77322024000200185</article-id>
<article-id pub-id-type="doi">10.51288/00840212</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Cribado prenatal de aneuploidías mediante análisis de ácido desoxirribonucleíco libre total circulante en plasma materno. Revisión narrativa.]]></article-title>
<article-title xml:lang="en"><![CDATA[Prenatal screening for aneuploidies by analysis of circulating total free deoxyribonucleic acid in maternal plasma. Narrative review]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Morales de Machín]]></surname>
<given-names><![CDATA[Alisandra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Machín Cáceres]]></surname>
<given-names><![CDATA[Enrique]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,La Universidad del Zulia Facultad de Medicina Instituto de Investigaciones Genéticas]]></institution>
<addr-line><![CDATA[Maracaibo ]]></addr-line>
<country>Venezuela</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Clínica de ojos  ]]></institution>
<addr-line><![CDATA[Maracaibo ]]></addr-line>
<country>Venezuela</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2024</year>
</pub-date>
<volume>84</volume>
<numero>2</numero>
<fpage>185</fpage>
<lpage>204</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_arttext&amp;pid=S0048-77322024000200185&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_abstract&amp;pid=S0048-77322024000200185&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_pdf&amp;pid=S0048-77322024000200185&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La prueba prenatal no invasiva es un método de cribado de aneuploidías fetales y de resultar con riesgo alto debe ser confirmado a través de prueba genética diagnóstica. Es la prueba de detección más sensible y específica para las aneuploidías fetales comunes y minimiza la realización de técnicas invasivas, solo para las gestantes con riesgo elevado. Se debe realizar asesoramiento genético pre- y poscribado. Este estudio tiene como objetivo describir los fundamentos básicos de la prueba prenatal no invasiva mediante el análisis del ácido desoxirribonucleíco libre circulante en plasma materno para cribado de aneuploidías, y de los métodos primordiales y avances en biología molecular incluyendo las tecnologías de secuenciación de nueva generación, que lo han facilitado, considerando sus beneficios y limitaciones al aplicarla en la práctica clínica, en este campo que cambia con tanta rapidez.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[SUMMARY The non-invasive prenatal test is a screening method for fetal aneuploidies and if the result is at high risk, it must be confirmed through diagnostic genetic test. It is the most sensitive and specific detection test for common fetal aneuploidies and minimizes the use of invasive techniques, only for pregnant women at high risk. Genetic counseling should be performed before and after screening. This study aims to describe the basic fundamentals of non-invasive prenatal testing by analyzing free circulating deoxyribonucleic acid in maternal plasma for aneuploidy screening, and the primary methods and advances in molecular biology, including next-generation sequencing technologies, which have facilitated it, considering its benefits and limitations when applying it in clinical practice, in this rapidly changing field.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Cribado prenatal]]></kwd>
<kwd lng="es"><![CDATA[Aneuploidías]]></kwd>
<kwd lng="es"><![CDATA[Ácido desoxirribonucleíco fetal libre]]></kwd>
<kwd lng="es"><![CDATA[Avances en biología molecular]]></kwd>
<kwd lng="es"><![CDATA[Secuenciación de nueva generación]]></kwd>
<kwd lng="es"><![CDATA[Asesoramiento genético]]></kwd>
<kwd lng="en"><![CDATA[Prenatal screening]]></kwd>
<kwd lng="en"><![CDATA[Aneuploidy]]></kwd>
<kwd lng="en"><![CDATA[Free fetal deoxyribonucleic acid]]></kwd>
<kwd lng="en"><![CDATA[Advances in molecular biology]]></kwd>
<kwd lng="en"><![CDATA[Next generation sequencing]]></kwd>
<kwd lng="en"><![CDATA[Genetic counseling]]></kwd>
</kwd-group>
</article-meta>
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<surname><![CDATA[Reiser]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Schaefer]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Adults&#8217; perceptions of genetic counseling and genetic testing]]></article-title>
<source><![CDATA[App Nurs Res]]></source>
<year>2015</year>
<volume>28</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>25-30</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
