<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0048-7732</journal-id>
<journal-title><![CDATA[Revista de Obstetricia y Ginecología de Venezuela]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Obstet Ginecol Venez]]></abbrev-journal-title>
<issn>0048-7732</issn>
<publisher>
<publisher-name><![CDATA[Sociedad de Obstetricia y Ginecología de Venezuela]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0048-77322024000300279</article-id>
<article-id pub-id-type="doi">10.51288/00840309</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Exosomas como tratamiento alternativo del síndrome genitourinario de la menopausia]]></article-title>
<article-title xml:lang="en"><![CDATA[Exosomes as an alternative treatment for genitourinary syndrome of menopause]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gómez Cárdenas]]></surname>
<given-names><![CDATA[Maryory]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Centro Occidental &#8220;Lisandro Alvarado&#8221;  ]]></institution>
<addr-line><![CDATA[Barquisimeto Lara]]></addr-line>
<country>Venezuela</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2024</year>
</pub-date>
<volume>84</volume>
<numero>3</numero>
<fpage>279</fpage>
<lpage>288</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_arttext&amp;pid=S0048-77322024000300279&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_abstract&amp;pid=S0048-77322024000300279&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_pdf&amp;pid=S0048-77322024000300279&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Objetivo: Evaluar el efecto de los exosomas como tratamiento alternativo en la restauración del síndrome genitourinario de la menopausia en pacientes que acuden a una consulta ginecológica, en Valencia, Estado Carabobo, en el período junio - agosto de 2023.  Métodos: Estudio prospectivo, descriptivo, exploratorio, incluyó tres casos de mujeres con diagnóstico de síndrome genitourinario de la menopausia. Se evaluó la respuesta en cuanto a los síntomas, examen clínico según el índice de salud vaginal, la satisfacción con el tratamiento y la tolerabilidad. Se aplicó el tratamiento con exosomas: 2 cc con técnica de punto a punto en todas las paredes vaginales y 1 cc en el vestíbulo, en 3 sesiones, con intervalo de 15 días.  Resultados: La edad de las pacientes estuvo entre 53 y 56 años, con un promedio de tiempo de menopausia de 6,6 años. Previo al tratamiento, había un nivel alto de irritación vaginal (100 %), dolor en el introito (100 %), sequedad vaginal, dispareunia, hipersensibilidad y las no relaciones sexuales (66,67 %). Postratamiento predominó la ausencia de los síntomas: sequedad vaginal, dispareunia, hipersensibilidad y dolor en introito (100 %); irritación vaginal y no relaciones sexuales (66,67 %) (p= 0,0001). La mediana del índice de salud vaginal previa fue 13 (10 - 13) y posterior fue 18 (17 - 20) (p= 0,0476). La satisfacción y tolerabilidad fue de 66,67 %. Una paciente refirió dolor leve.  Conclusión: La terapia con exosomas es eficaz para reducir los síntomas y signos del síndrome genitourinario de la menopausia, y bien tolerado.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[SUMMARY  Objective:  To evaluate the effect of exosomes as an alternative treatment in the restoration of genitourinary syndrome of menopause in patients attending a gynecological consultation in Valencia, Carabobo State, in the period June - August 2023.  Methods:  A prospective, descriptive, exploratory study included three cases of women diagnosed with genitourinary syndrome of menopause. Response was assessed in terms of symptoms, clinical examination according to vaginal health index, satisfaction with treatment and tolerability. Treatment with exosomes was applied: 2 cc with point-to-point technique on all vaginal walls and 1 cc in the vestibule, in 3 sessions, with an interval of 15 days.  Results:  The age of the patients was between 53 and 56 years, with a mean menopause time of 6.6 years. Prior to treatment, there was a high level of vaginal irritation (100%), pain in the introitus (100%), vaginal dryness, dyspareunia, hypersensitivity and non-sexual intercourse (66.67%). Post-treatment, the absence of symptoms predominated: vaginal dryness, dyspareunia, hypersensitivity and pain in the introitus (100%); vaginal irritation and no sexual intercourse (66.67%) (p = 0.0001). The median index of previous vaginal health was 13 (10 - 13) and subsequent was 18 (17 - 20) (p = 0.0476). Satisfaction and tolerability was 66.67%. One patient reported mild pain.  Conclusion:  Exosome therapy is effective in reducing the symptoms and signs of genitourinary syndrome of menopause, and well tolerated.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Síndrome genitourinario de la menopausia]]></kwd>
<kwd lng="es"><![CDATA[Atrofia vulvovaginal]]></kwd>
<kwd lng="es"><![CDATA[Exosomas]]></kwd>
<kwd lng="en"><![CDATA[Genitourinary syndrome of menopause]]></kwd>
<kwd lng="en"><![CDATA[Vulvovaginal atrophy]]></kwd>
<kwd lng="en"><![CDATA[Exosomes]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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