<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0535-5133</journal-id>
<journal-title><![CDATA[Investigación Clínica]]></journal-title>
<abbrev-journal-title><![CDATA[Invest. clín]]></abbrev-journal-title>
<issn>0535-5133</issn>
<publisher>
<publisher-name><![CDATA[Instituto de Investigaciones Clínicas "Dr. Américo Negrette", Facultad de Medicina, Universidad del Zulia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0535-51332021000100028</article-id>
<article-id pub-id-type="doi">10.22209/ic.v62n1a03</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[The value of GeneXpert MTB/RIF in bronchoalveolar lavage fluid in the diagnosis of smear-negative pulmonary tuberculosis.]]></article-title>
<article-title xml:lang="es"><![CDATA[Valor de GeneXpert MTB / RIF en líquido de lavado broncoalveolar en el diagnóstico de tuberculosis pulmonary con frotis negativo]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zhou]]></surname>
<given-names><![CDATA[Yue-Ying]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Shi]]></surname>
<given-names><![CDATA[Ji-Chan]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pan]]></surname>
<given-names><![CDATA[Ning]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Wu]]></surname>
<given-names><![CDATA[Zheng-Xing]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cheng]]></surname>
<given-names><![CDATA[Ai-Qiong]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mei]]></surname>
<given-names><![CDATA[Yan-Hong]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Wu]]></surname>
<given-names><![CDATA[Lian-Peng]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jiang]]></surname>
<given-names><![CDATA[Xian-Gao]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Wenzhou Central Hospital Department of Infectious Diseases ]]></institution>
<addr-line><![CDATA[Wenzhou Zhejiang]]></addr-line>
<country>China</country>
</aff>
<pub-date pub-type="pub">
<day>31</day>
<month>03</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>31</day>
<month>03</month>
<year>2021</year>
</pub-date>
<volume>62</volume>
<numero>1</numero>
<fpage>28</fpage>
<lpage>36</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_arttext&amp;pid=S0535-51332021000100028&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_abstract&amp;pid=S0535-51332021000100028&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_pdf&amp;pid=S0535-51332021000100028&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract This study aims to evaluate the diagnostic value of Xpert MTB/ RIF assay in bronchoalveolar lavage fluid (BALF) in subjects with smear-negative pulmonary tuberculosis. From January 2019 to December 2019, 197 patients with suspected pulmonary tuberculosis were recruited, and bronchoalveolar lavage fluid was collected for acid-fast staining smear, liquid culture of Mycobacterium combined drug sensitivity and Xpert MTB/RIF detection. The sensitivity, specificity, positive predictive value and negative predictive value of Xpert MTB/RIF in bronchoalveolar lavage fluid (BALF) were calculated with smear-negative pulmonary tuberculosis as the reference standard. The consistency of xpert MTB/RIF in the diagnosis of rifampicin resistance was evaluated, with the results of Mycobacterium liquid culture drug sensitivity test and drug sensitivity test as the gold standards. The results showed that among 197 suspected tuberculosis patients, 55 patients were not diagnosed with tuberculosis and 142 patients were diagnosed with smear-negative pulmonary tuberculosis. One hundred and twenty three cases (86.62%) were positive for Xpert MTB/ RIF in bronchoalveolar lavage fluid, 15 cases (10.56%) were positive by acid-fast staining smear method, and 88 cases (61.97%) were positive by the liquid culture method. The positive rate of Xpert MTB / RIF was 93.18% (82 / 88), which was higher than that of 75.93% (41 / 54) of the negative BALF mycobacterium culture (&#967; 2 = 8.598, P&lt;0.01). The sensitivity and specificity of Xpert MTB/RIF for rifampicin resistance were 100.00% and 97.30%, respectively. Therefore, the diagnostic value of Xpert MTB/RIF in bronchoalveolar lavage fluid for bacterial-negative pulmonary tuberculosis is superior to the acid-fast staining smear of lavage fluid and the mycobacterium culture method.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Este estudio tiene como objetivo evaluar el valor de Xpert MTB/ RIF en líquido de lavado broncoalveolar (BALF) en el diagnóstico de tuberculosis pulmonar con frotis negativo. Se reclutaron 197 pacientes con sospecha de tuberculosis pulmonar desde enero de 2019 hasta diciembre de 2019 y se recogió líquido de lavado broncoalveolar para frotis de tinción acido-resistente, cultivo en medio líquido de sensibilidad a fármacos combinados de Mycobacterium y detección de Xpert MTB/RIF. Se calcularon la sensibilidad, especificidad, valor predictivo positivo y valor predictivo negativo de Xpert MTB/RIF en el líquido de lavado broncoalveolar (BALF), con tuberculosis pulmonar con frotis negativo como estándar de referencia. La consistencia de Xpert MTB/RIF en el diagnóstico de resistencia a la rifampicina se evaluó con los resultados de la prueba de sensibilidad al fármaco en cultivo en medio líquido de Mycobacterium y la prueba de sensibilidad al fármaco como patrón oro. Los resultados mostraron que entre 197 pacientes sospechosos de tuberculosis, 55 no fueron diagnosticados con tuberculosis y 142 fueron diagnosticados con tuberculosis pulmonar con frotis negativo; 123 casos (86,62%) fueron positivos para Xpert MTB / RIF en el líquido de lavado broncoalveolar, 15 casos (10,56%) fueron positivos por el método de frotis de tinción ácido-resistente y 88 casos (61,97%) fueron positivos por el método de cultivo en medio líquido. La tasa positiva de Xpert MTB/RIF fue del 93,18% (82/88), que fue superior a la del 75,93% (41/54) del cultivo de micobacterias BALF negativo (&#967;2 = 8,598, P &lt;0,01). La sensibilidad y especificidad de Xpert MTB / RIF para la resistencia a la rifampicina fueron 100,00% y 97,30%, respectivamente. Por lo tanto, el valor de Xpert MTB/RIF en el líquido de lavado broncoalveolar en el diagnóstico de la tuberculosis pulmonar con frotis negativo, es superior al frotis de tinción acido-resistente del líquido de lavado y al método de cultivo de micobacterias.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[bronchoalveolar lavage fluid]]></kwd>
<kwd lng="en"><![CDATA[Xpert MTB/RIF]]></kwd>
<kwd lng="en"><![CDATA[tuberculosis]]></kwd>
<kwd lng="en"><![CDATA[Mycobacterium culture]]></kwd>
<kwd lng="en"><![CDATA[rifampicin resistance]]></kwd>
<kwd lng="es"><![CDATA[líquido de lavado broncoalveolar]]></kwd>
<kwd lng="es"><![CDATA[Xpert MTB / RIF]]></kwd>
<kwd lng="es"><![CDATA[tuberculosis]]></kwd>
<kwd lng="es"><![CDATA[cultivo de Mycobacterium]]></kwd>
<kwd lng="es"><![CDATA[resistencia a la rifampicina]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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