<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0535-5133</journal-id>
<journal-title><![CDATA[Investigación Clínica]]></journal-title>
<abbrev-journal-title><![CDATA[Invest. clín]]></abbrev-journal-title>
<issn>0535-5133</issn>
<publisher>
<publisher-name><![CDATA[Instituto de Investigaciones Clínicas "Dr. Américo Negrette", Facultad de Medicina, Universidad del Zulia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0535-51332023000300424</article-id>
<article-id pub-id-type="doi">10.54817/ic.v64n3a12</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Clinical efficacy and safety of folic acid and vitamin B12 for the adjuvant treatment of schizophrenia: a systematic review and meta-analysis.]]></article-title>
<article-title xml:lang="es"><![CDATA[Eficacia clínica y seguridad del ácido fólico y la vitamina B12 como tratamiento adyuvante de la esquizofrenia: una revisión sistemática y metanálisis.]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Niu]]></surname>
<given-names><![CDATA[Kai]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zhao]]></surname>
<given-names><![CDATA[Ximin]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Wei]]></surname>
<given-names><![CDATA[Ying]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[Yuefeng]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Zhoushan Second People&#8217;s Hospital Department of Psychiatry ]]></institution>
<addr-line><![CDATA[Zhoushan Zhejiang Province]]></addr-line>
<country>China</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Zhoushan Second People&#8217;s Hospital Medical Record Statistics Office ]]></institution>
<addr-line><![CDATA[Zhoushan Zhejiang Province]]></addr-line>
<country>China</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2023</year>
</pub-date>
<volume>64</volume>
<numero>3</numero>
<fpage>424</fpage>
<lpage>436</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_arttext&amp;pid=S0535-51332023000300424&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_abstract&amp;pid=S0535-51332023000300424&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_pdf&amp;pid=S0535-51332023000300424&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Given the different effects of folate and vitamin B12 on the adjuvant treatment of schizophrenia (SCH), their efficacy and safety as adjuvant therapies for SCH were systematically evaluated by evidence-based medicine. Publication retrieval was performed using authoritative databases such as the Cochrane Library, PubMed, and Web of Science to screen randomized controlled trials (RCTs). After the quality evaluation and data extraction of included studies, eligible RCTs were systematically reviewed using Review Manager 5.2 software. In total, 14 RCTs were included. The results of the meta-analysis revealed that as the adjuvant therapy for SCH, vitamin B12 differed significantly from folate in terms of anxiety relief rate [odds ratio (OR)=1.28, 95% confidence interval (CI) (1.02, 1.61), p=0.03, I 2 =0%, Z=2.13]. However, there were no significant differences in the incidence rate of mania [OR=1.13, 95% CI (0.78,1.65), p=0.65, I 2=36%, Z=0.65], total efficacy [OR=1.06, 95% CI (0.72, 1.56), p=0.77, I 2=0%, Z=0.30] and incidence rate of adverse reactions [OR=1.15, 95% CI (0.88, 1.49), p=0.31, I 2=0%, Z=1.03]. Although folate and vitamin B12 exhibit no significant differences in the adjuvant treatment of SCH, vitamin B12 exerts markedly fewer side effects than folate drugs, and it is of determinant significance for the clinical adjuvant medication of SCH.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen En vista de los diferentes efectos del folato y la vitamina B12 en el tratamiento adyuvante de la esquizofrenia (SCH), su eficacia y seguridad como terapia adyuvante para SCH fueron evaluadas sistemáticamente mediante la medicina basada en la evidencia. La recuperación de publicaciones se realizó en base a bases de datos autorizadas como Cochrane Library, PubMed y Web of Science para la selección de ensayos controlados aleatorios (ECA). Después de la evaluación de la calidad y la extracción de datos de los estudios incluidos, los ECA elegibles se revisaron sistemáticamente mediante el software Review Manager 5.2. En total, se incluyeron 14 ECA. Los resultados del metanálisis revelaron que, como terapia adyuvante para la SCH, la vitamina B12 difería significativamente del folato en términos de tasa de alivio de la ansiedad [odds ratio (OR) = 1,28, intervalo de confianza (IC) del 95% (1,02, 1,61), p=0,03, I 2=0%, Z=2,13], pero no hubo diferencias significativas en la tasa de incidencia de manía [OR=1,13, IC 95% (0,78,1,65), p=0,65, I 2=36%, Z= 0,65], eficacia total [OR=1,06, IC 95% (0,72, 1,56), p=0,77, I 2=0%, Z=0,30] y tasa de incidencia de reacciones adversas [OR=1,15, IC 95% (0,88, 1,49 ), p=0,31, I 2=0%, Z=1,03]. Aunque el folato y la vitamina B12 no presentan diferencias significativas en el tratamiento adyuvante de la SCH, la vitamina B12 ejerce notablemente menos efectos secundarios que los fármacos de folato y tiene una importancia orientativa para la medicación adyuvante clínica de la SCH.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[folic acid]]></kwd>
<kwd lng="en"><![CDATA[meta-analysis]]></kwd>
<kwd lng="en"><![CDATA[schizophrenia]]></kwd>
<kwd lng="en"><![CDATA[vitamin B12]]></kwd>
<kwd lng="es"><![CDATA[ácido fólico]]></kwd>
<kwd lng="es"><![CDATA[metanálisis]]></kwd>
<kwd lng="es"><![CDATA[esquizofrenia]]></kwd>
<kwd lng="es"><![CDATA[vitamina B12]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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