<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0535-5133</journal-id>
<journal-title><![CDATA[Investigación Clínica]]></journal-title>
<abbrev-journal-title><![CDATA[Invest. clín]]></abbrev-journal-title>
<issn>0535-5133</issn>
<publisher>
<publisher-name><![CDATA[Instituto de Investigaciones Clínicas "Dr. Américo Negrette", Facultad de Medicina, Universidad del Zulia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0535-51332023000400482</article-id>
<article-id pub-id-type="doi">10.54817/ic.v64n4a05</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Effects of SU5416 on angiogenesis and the ERK-VEGF/MMP-9 pathway in rat endometriosis.]]></article-title>
<article-title xml:lang="es"><![CDATA[Efecto del SU5416 sobre la angiogenesis y la via ERK-VEGF/MMP-9 en la endometriosis de ratas.]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zhao]]></surname>
<given-names><![CDATA[Danyang]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bao]]></surname>
<given-names><![CDATA[Qiufang]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[Lihong]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A3"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zheng]]></surname>
<given-names><![CDATA[Lie]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Fujian Medical University First Affiliated Hospital Department of Obstetrics and Gynecology]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>China</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Fujian Medical University National Regional Medical Center, Binhai Campus of the First Affiliated Hospital Department of Gynecology]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>China</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Fujian Medical University First Affiliated Hospital Fujian Key Laboratory of Precision Medicine for Cancer]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>China</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<volume>64</volume>
<numero>4</numero>
<fpage>482</fpage>
<lpage>494</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_arttext&amp;pid=S0535-51332023000400482&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_abstract&amp;pid=S0535-51332023000400482&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_pdf&amp;pid=S0535-51332023000400482&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract SU5416 is a small molecule vascular endothelial growth factor (VEGF) receptor signal transduction inhibitor, which can block the VEGF receptor autophosphorylation and inhibit receptor tyrosine kinase signal transduction, thereby reducing VEGF activity. However, there are few reports about the correlation of SU5416 to the occurrence and angiogenesis in endometriosis. In this study, we observed the effects of VEGF receptor inhibitor SU5416 on angiogenesis in endometriosis in rats. Thirty female specific-pathogen-free Sprague-Dawley rats were randomly divided into sham operation group (SOG), model group (MG), and SU5416 group (n=10 for each group). In the SOG, only the uterus was cut and sutured, and endometriosis models were established in the MG and SU5416 group by autologous transplantation. The SU5416 group was injected with 15 mg/kg SU5416 intraperitoneally, and the SOG and MG were intraperitoneally injected with an equal volume of normal saline for 6 weeks. The volume of ectopic lesions was lower in the SU5416 group at 42 d postoperatively than in the MG (p&lt;0.05). The proportion of CD31-positive cells in the endometrial tissue of the SU5416 group was lower than that of the MG (p&lt;0.05); angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), laminin-5&#947;2 (LN-5&#947;2) and phosphorylation of ERK (P-ERK), VEGF, matrix metalloproteinase (MMP)-2, and MMP-9 protein expressions were lower in the SU5416 group than in the MG (p&lt;0.05). VEGF receptor inhibitor SU5416 can inhibit endometriosis angiogenesis and reduce inflammatory response in rats, and its mechanism of action may be related to the down-regulation of the ERK-VEGF/MMP-9 pathway expression.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen SU5416 es un inhibidor de la transducción de señales del receptor del factor de crecimiento endotelial vascular (VEGF), una molécula pequeña, capaz de bloquear la autofosforilación del receptor VEGF e inhibir la transducción de señales de la tirosina quinasa del receptor, reduciendo así la actividad del VEGF. Sin embargo, existen escasos informes acerca de la correlación entre SU5416 y la aparición y angiogénesis de la endometriosis. En este estudio, hemos observado los efectos del inhibidor del receptor del VEGF, SU5416, sobre la angiogénesis en la endometriosis en ratas. Treinta ratas Sprague-Dawley hembra, libres de patógenos específicos, fueron divididas aleatoriamente en un grupo de operación simulada (SOG), un grupo de modelo (MG) y un grupo de SU5416 (n=10 en cada grupo). En el SOG, solo se realizó una incisión en el útero y se suturó, mientras que en los grupos MG y SU5416 se establecieron modelos de endometriosis mediante trasplante autólogo. Al grupo SU5416 se le inyectaron 15 mg/kg de SU5416 por vía intraperitoneal, y tanto el SOG como el MG recibieron una inyección intraperitoneal de un volumen igual de solución salina normal durante 6 semanas. El volumen de lesiones ectópicas fue menor en el grupo SU5416 a los 42 días después de la operación en comparación con el MG (p&lt;0,05); la proporción de células CD31 positivas en el tejido endometrial del grupo SU5416 fue inferior a la del MG (p&lt;0,05); las expresiones de las proteínas angiopoyetina-1 (Ang-1), angiopoyetina-2 (Ang-2), laminina-5&#947;2 (LN-5&#947;2) y la fosforilación de ERK (P-ERK), VEGF, metaloproteinasa de matriz (MMP)-2 y MMP-9 fueron menores en el grupo SU5416 que en el MG (p&lt;0,05). El inhibidor del receptor del VEGF, SU5416, puede inhibir la angiogénesis de la endometriosis y reducir la respuesta inflamatoria en ratas, y su mecanismo de acción puede estar relacionado con la regulación a la baja de la expresión de la vía ERK-VEGF/MMP-9.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[angiogenesis]]></kwd>
<kwd lng="en"><![CDATA[endometriosis]]></kwd>
<kwd lng="en"><![CDATA[ERK-VEGF/MMP-9 pathway]]></kwd>
<kwd lng="en"><![CDATA[SU5416]]></kwd>
<kwd lng="es"><![CDATA[angiogénesis]]></kwd>
<kwd lng="es"><![CDATA[endometriosis]]></kwd>
<kwd lng="es"><![CDATA[vía ERK-VEGF/MMP-9]]></kwd>
<kwd lng="es"><![CDATA[SU5416]]></kwd>
</kwd-group>
</article-meta>
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