<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0535-5133</journal-id>
<journal-title><![CDATA[Investigación Clínica]]></journal-title>
<abbrev-journal-title><![CDATA[Invest. clín]]></abbrev-journal-title>
<issn>0535-5133</issn>
<publisher>
<publisher-name><![CDATA[Instituto de Investigaciones Clínicas "Dr. Américo Negrette", Facultad de Medicina, Universidad del Zulia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0535-51332023000400513</article-id>
<article-id pub-id-type="doi">10.54817/ic.v64n4a08</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Stress-associated ovarian damage, infertility, and delay in achieving pregnancy and treatment options.]]></article-title>
<article-title xml:lang="es"><![CDATA[Daño ovárico, infertilidad y retraso en la concepción relacionados con el estrés y opciones de tratamiento.]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aynaoglu Yildiz]]></surname>
<given-names><![CDATA[Gulsah]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Yapca]]></surname>
<given-names><![CDATA[Omer Erkan]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Dinc]]></surname>
<given-names><![CDATA[Kemal]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gursul]]></surname>
<given-names><![CDATA[Cebrail]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gundogdu]]></surname>
<given-names><![CDATA[Betul]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aktas]]></surname>
<given-names><![CDATA[Mehmet]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Suleyman]]></surname>
<given-names><![CDATA[Zeynep]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bulut]]></surname>
<given-names><![CDATA[Seval]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Suleyman]]></surname>
<given-names><![CDATA[Halis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Etlik Zubeyde Hanim Maternity and Women&#8217;s Health Teaching and Research Hospital Department of Perinatology ]]></institution>
<addr-line><![CDATA[Ankara ]]></addr-line>
<country>Turkey</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Ataturk University Faculty of Medicine Department of Obstetrics and Gynaecology]]></institution>
<addr-line><![CDATA[Erzurum ]]></addr-line>
<country>Turkey</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Erzincan Binali Yildirim University Faculty of Medicine Department of Obstetrics and Gynaecology]]></institution>
<addr-line><![CDATA[Erzincan ]]></addr-line>
<country>Turkey</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Erzincan Binali Yildirim University Faculty of Medicine Department of Physiology]]></institution>
<addr-line><![CDATA[Erzincan ]]></addr-line>
<country>Turkey</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Ataturk University Faculty of Medicine Department of Pathology]]></institution>
<addr-line><![CDATA[Erzurum ]]></addr-line>
<country>Turkey</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Erzincan Binali Yildirim University Faculty of Medicine Department of Biochemistry]]></institution>
<addr-line><![CDATA[Erzincan ]]></addr-line>
<country>Turkey</country>
</aff>
<aff id="Af7">
<institution><![CDATA[,Erzincan Binali Yildirim University Health Sciences Institute Department of Pharmacology]]></institution>
<addr-line><![CDATA[Erzincan ]]></addr-line>
<country>Turkey</country>
</aff>
<aff id="Af8">
<institution><![CDATA[,Erzincan Binali Yildirim University Faculty of Medicine Department of Pharmacology]]></institution>
<addr-line><![CDATA[Erzincan ]]></addr-line>
<country>Turkey</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<volume>64</volume>
<numero>4</numero>
<fpage>513</fpage>
<lpage>523</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_arttext&amp;pid=S0535-51332023000400513&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_abstract&amp;pid=S0535-51332023000400513&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_pdf&amp;pid=S0535-51332023000400513&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Many types of stress, including psychological stress, negatively affect reproductive health. This study aimed to investigate the effects of sertraline (a selective serotonin reuptake inhibitor), cerebrolysin (neuroprotective/neurotrophic), and a combination of both against stress- induced ovarian damage, infertility and pregnancy delay in female rats. The rats were divided into five groups (n=14/each group) as healthy (HG), stress control (StC), stress+sertraline (SS), stress+cerebrolysin (SC), and stress+sertraline+cerebrolysin (SSC). To induce stress, animals (except the HG) were kept in a supine position with their forelimbs and hindlimbs (FIM) tied for one hour. Then, sertraline (20mg/kg) was given orally to the SS. Cerebrolysin (2.5ml/kg) was injected into the SC subcutaneously. Sertraline+cerebrolysin was administered to SSC with the same methods and doses. FIM and drug administration continued for 30 days. Six rats from each group were euthanized with high-dose anesthesia, right and left ovarian tissues were removed, and tissues were examined biochemically and histopathologically. The remaining rats were taken for breeding. Exposure to stress in rats caused an increase in malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-&#945;), interleukin-1&#946; (IL -1&#946;), and interleukin-6 (IL -6) levels and a decrease in total glutathione (tGSH). Stress was related to histopathological damage, infertility, and delayed birth. The sertraline and cerebrolysin combination was the most effective in preventing these changes, with sertraline and cerebrolysin alone in second and third places, respectively. Regarding efficacy, selective serotonin reuptake inhibitors (SSRIs) and related drugs may be beneficial in treating stress-related ovarian damage, infertility, and delay in pregnancy.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Muchos tipos de estrés, incluido el estrés psicológico, afectan negativamente a la salud reproductiva. El objetivo de este estudio fue investigar los efectos de la sertralina (un inhibidor selectivo de la recaptación de serotonina), la cerebrolisina (neuroprotector/neurotrófico) y una combinación de ambos contra el daño ovárico, la infertilidad y el retraso del embarazo inducido por el estrés en ratas hembra. Las ratas se dividieron en cinco grupos (n=14/ cada grupo), como sanas (HG), control de estrés (StC), estrés+sertralina (SS), estrés+cerebrolisina (SC) y estrés+sertralina+cerebrolisina (SSC) . Para inducir el estrés, los animales (excepto el HG) se mantuvieron en posición supina con las extremidades anteriores y posteriores (FIM) atadas durante una hora. Luego, se administró sertralina (20 mg/kg) por vía oral al grupo SS. Cerebrolysin (2,5 mL/kg) se inyectó al grupo SC por vía subcutánea. Se administró sertralina+cerebrolisina al grupo SSC con los mismos métodos y dosis. La FIM y la administración de fármacos continuaron durante 30 días. Se sacrificaron seis ratas de cada grupo con anestesia de dosis alta, se extirparon los tejidos de los ovarios derecho e izquierdo y se examinaron bioquímica e histopatológicamente. Las ratas restantes se tomaron para reproducción. La exposición al estrés en ratas provocó un aumento de los niveles de malondialdehído (MDA), factor de necrosis tumoral alfa (TNF-&#945;), interleucina-1&#946; (IL -1&#946;) e interleucina-6 (IL -6) y una disminución del glutatión total (tGSH). El estrés se relacionó con daño histopatológico, infertilidad y retraso en el parto. La combinación de sertralina y cerebrolisina fue la más efectiva para prevenir estos cambios, con sertralina y cerebrolisina solas en segundo y tercer lugar, respectivamente. Los inhibidores selectivos de la recaptación de serotonina (ISRS) y los medicamentos relacionados pueden ser beneficiosos en el tratamiento del daño ovárico relacionado con el estrés, la infertilidad y el retraso en el embarazo.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[ovarian damage]]></kwd>
<kwd lng="en"><![CDATA[sertraline]]></kwd>
<kwd lng="en"><![CDATA[cerebrolysin]]></kwd>
<kwd lng="en"><![CDATA[stress]]></kwd>
<kwd lng="en"><![CDATA[rats]]></kwd>
<kwd lng="es"><![CDATA[daño ovárico]]></kwd>
<kwd lng="es"><![CDATA[sertralina]]></kwd>
<kwd lng="es"><![CDATA[cerebrolisina]]></kwd>
<kwd lng="es"><![CDATA[estrés]]></kwd>
<kwd lng="es"><![CDATA[ratas]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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