<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0535-5133</journal-id>
<journal-title><![CDATA[Investigación Clínica]]></journal-title>
<abbrev-journal-title><![CDATA[Invest. clín]]></abbrev-journal-title>
<issn>0535-5133</issn>
<publisher>
<publisher-name><![CDATA[Instituto de Investigaciones Clínicas "Dr. Américo Negrette", Facultad de Medicina, Universidad del Zulia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0535-51332025000100078</article-id>
<article-id pub-id-type="doi">10.54817/ic.v66n1a07</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[The role of 5-fluorouracil in Wnt/&#946;-catenin signalling in human papillomavirus-positive cervical cancer cells.]]></article-title>
<article-title xml:lang="es"><![CDATA[Función del 5-fluorouracilo en la señalización Wnt/&#946;-catenina en células de cáncer de cuello uterino positivas al virus del papiloma humano.]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Wen]]></surname>
<given-names><![CDATA[Lifang]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Liang]]></surname>
<given-names><![CDATA[Xiaojun]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ding]]></surname>
<given-names><![CDATA[Jie]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[Haijuan]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[Peili]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Fenyang College of Shanxi Medical University Department of Obstetrics and Gynecology Teaching and Research ]]></institution>
<addr-line><![CDATA[Fenyang Shanxi]]></addr-line>
<country>China</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Shanxi Fenyang Hospital Department of Obstetrics and Gynecology ]]></institution>
<addr-line><![CDATA[Fenyang Shanxi]]></addr-line>
<country>China</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Shanxi Fenyang Hospital Department of Interventional ]]></institution>
<addr-line><![CDATA[Fenyang Shanxi]]></addr-line>
<country>China</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Fenyang College of Shanxi Medical University Department of Pathology Student Science Teaching and Research Office ]]></institution>
<addr-line><![CDATA[Fenyang Shanxi]]></addr-line>
<country>China</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2025</year>
</pub-date>
<volume>66</volume>
<numero>1</numero>
<fpage>78</fpage>
<lpage>88</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_arttext&amp;pid=S0535-51332025000100078&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_abstract&amp;pid=S0535-51332025000100078&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_pdf&amp;pid=S0535-51332025000100078&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Human papillomavirus (HPV) infection is a major risk factor for cervical cancer, especially persistent infection with high-risk HPV. 5-fluorouracil (5-FU) is a widely used antimetabolite chemotherapeutic agent that inhibits the proliferation of tumour cells by interfering with ribonucleic acid and deoxyribonucleic acid synthesis; however, its mechanism of action has not been fully elucidated. This study aimed to investigate the role of Wnt/&#946;-catenin signalling in patients with high-risk HPV with cervical cancer treated with 5-FU. Patients with high-risk HPV-positive cervical cancer treated with surgery were taken as the research participants, and lesion tissues were collected during surgery. Human HPV-positive cervical cancer cells were isolated and cultured in vitro by the enzyme combined digestion method, and the obtained cells were divided into a control group, a paclitaxel group and a 5-FU group. A 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay was used to measure the proliferation of high-risk HPV-positive cervical cancer cells under different treatment conditions. Western blotting was used to evaluate the protein expression level of the Wnt/&#946;-catenin signalling pathway in cells, and flow cytometry was used to analyse the level of T lymphocytes in the patients&#8217; blood. The results of the MTT assay showed that the proliferation rate of cervical cancer cells in the control group was significantly higher than that in the paclitaxel group and the 5-FU group at all detection time points (p&lt;0.05). The expression levels of Wnt/&#946;-catenin protein in the 5-FU group were lower than those in the paclitaxel and the control groups (p&lt;0.05). The results of the T lymphocyte level comparison showed that the ratios of CD3+ T cells, CD4+ T cells and CD4+/CD8+ cells affected by 5-FU were higher than those before treatment (p&lt;0.05). 5-fluorouracil can significantly reduce the expression level of Wnt/&#946;-catenin protein and increase the T lymphocyte levels in cervical cancer cells.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La infección por el virus del papiloma humano (HPV) es un factor de riesgo importante para el cáncer de cuello uterino, especialmente la infección persistente con HPV de alto riesgo. El 5-fluorouracilo (5-FU) es un agente quimioterapéutico antimetabólico ampliamente utilizado que inhibe la proliferación de las células tumorales al interferir con la síntesis de ARN y ADN, pero su mecanismo de acción no ha sido completamente elucidado. Para investigar el papel de la señalización Wnt/&#946;-catenina en los pacientes con cáncer de cuello uterino de alto riesgo HPV tratados con 5-FU. Los pacientes con cáncer de cuello uterino positivo para HPV de alto riesgo tratados con cirugía fueron tomados como objetos de investigación, y se recolectaron tejidos lesionales durante la cirugía. Se aislaron y cultivaron in vitro células de cáncer de cuello uterino positivas para HPV humano mediante el método de digestión combinada enzimática, y las células obtenidas se dividieron en un grupo de control, un grupo de paclitaxel y un grupo de 5-fluorouracilo. El MTT se utilizó para medir la proliferación de las células de cáncer de cuello uterino positivas para HPV de alto riesgo bajo diferentes condiciones de tratamiento. La técnica de western blot se utilizó para evaluar el nivel de expresión proteica de la vía de señalización Wnt/&#946;-catenina en las células. La citometría de flujo se utilizó para analizar el nivel de linfocitos T en la sangre del paciente. Los resultados del ensayo MTT mostraron que la tasa de proliferación de las células de cáncer de cuello uterino en el grupo de control fue significativamente mayor que en el grupo de paclitaxel y el grupo de 5-fluorouracilo en todos los puntos de detección (p&lt;0,05). Los niveles de expresión de la proteína Wnt/&#946;-catenina en el grupo de 5-fluorouracilo fueron inferiores a los del grupo de paclitaxel y el grupo de control (p&lt;0,05). Los resultados de la comparación del nivel de linfocitos T mostraron que las proporciones de células T CD3+, células T CD4+ y células CD4+/CD8+ afectadas por el 5-fluorouracilo fueron más altas que antes del tratamiento (p&lt;0,05). El 5-fluorouracilo puede reducir significativamente el nivel de expresión de la proteína Wnt/&#946;-catenina y aumentar la actividad del nivel de linfocitos T en las células de cáncer de cuello uterino.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[5-fluorouracil]]></kwd>
<kwd lng="en"><![CDATA[high-risk HPV-positive cervical cancer cells]]></kwd>
<kwd lng="en"><![CDATA[T lymphocytes]]></kwd>
<kwd lng="en"><![CDATA[Wnt/&#946;-catenin signalling pathway]]></kwd>
<kwd lng="en"><![CDATA[apoptosis]]></kwd>
<kwd lng="es"><![CDATA[5-fluorouracilo]]></kwd>
<kwd lng="es"><![CDATA[células de cáncer de cuello uterino positivas al VPH de alto riesgo]]></kwd>
<kwd lng="es"><![CDATA[linfocitos T]]></kwd>
<kwd lng="es"><![CDATA[vía de señalización Wnt/&#946;-catenina]]></kwd>
<kwd lng="es"><![CDATA[apoptosis]]></kwd>
</kwd-group>
</article-meta>
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