<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0535-5133</journal-id>
<journal-title><![CDATA[Investigación Clínica]]></journal-title>
<abbrev-journal-title><![CDATA[Invest. clín]]></abbrev-journal-title>
<issn>0535-5133</issn>
<publisher>
<publisher-name><![CDATA[Instituto de Investigaciones Clínicas "Dr. Américo Negrette", Facultad de Medicina, Universidad del Zulia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0535-51332025000300234</article-id>
<article-id pub-id-type="doi">10.54817/ic.v66n3a01</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[A preliminary investigation of the association between KRAS, NRAS, and BRAF mutations and colorectal cáncer in Turkish patients.]]></article-title>
<article-title xml:lang="es"><![CDATA[Una investigación preliminar sobre la asociación entre mutaciones KRAS, NRAS y BRAF en cáncer colorrectal en pacientes Turcos.]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Devrim]]></surname>
<given-names><![CDATA[Tuba]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sevim Tuncer]]></surname>
<given-names><![CDATA[Saniye]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Erk&#305;l&#305;nç]]></surname>
<given-names><![CDATA[Gamze]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Izmir Bakircay University  ]]></institution>
<addr-line><![CDATA[Izmir ]]></addr-line>
<country>Türkiye</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Ministry of Health Çi&#287;li Training and Research Hospital Department of Medical Pathology]]></institution>
<addr-line><![CDATA[Izmir ]]></addr-line>
<country>Türkiye</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2025</year>
</pub-date>
<volume>66</volume>
<numero>3</numero>
<fpage>234</fpage>
<lpage>240</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_arttext&amp;pid=S0535-51332025000300234&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_abstract&amp;pid=S0535-51332025000300234&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_pdf&amp;pid=S0535-51332025000300234&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Somatic mutations in the GTPase RAS protein family and the downstream serine-threonine kinase BRAF are predicted to be key driver mutations in colorectal carcinogenesis by disrupting critical control points in cell cycle regulation. In our study, we aimed to investigate the relationship between KRAS, NRAS, and BRAF mutations in colorectal cancer (CRC) samples and corresponding clinicopathological data. This retrospective study included 64 CRC patients who were evaluated for KRAS, NRAS, and BRAF mutations in our department between 2022 and 2024. The findings were evaluated according to the age, gender, tumor localization in the colon, and histopathological subtype of the patients in whom the mutation was detected, and the relationships between these variables were analyzed using the chi-square test. KRAS mutations were detected at 29.6%, NRAS mutations at 3.1% and BRAF mutations at 1.6%. No significant relationship was found between mutation rates and the patients&#8217; age, gender and colon localization. Our study demonstrated that mutations in KRAS, NRAS, and BRAF were not associated with the age, sex, and tumor location of CRC patients. The data presented are preliminary findings, and more research is needed to evaluate the clinical and pathological impact of these mutations on colorectal cancer progression and outcomes.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Se predice que las mutaciones somáticas en la familia de las proteínas GTPasa RAS y la serina-treonina quinasa BRAF son mutaciones clave en la carcinogénesis colorrectal al interrumpir puntos de control críticos en la regulación del ciclo celular. En este estudio, el objetivo fue evaluar la relación entre las mutaciones KRAS, NRAS y BRAF en muestras de cáncer colorrectal (CCR) y datos clinicopatológicos. Este estudio retrospectivo incluyó a 64 pacientes con CCR que fueron evaluados para mutaciones en KRAS, NRAS y BRAF en nuestro servicio entre 2022-2024. Los hallazgos se evaluaron según la edad, el sexo, la localización del tumor en el colon y el subtipo histopatológico de los pacientes en los que se detectó la mutación, y se analizaron las relaciones entre ellos mediante la prueba de chi-cuadrado. Las mutaciones en KRAS se detectaron en un 29,6%, en NRAS en un 3,1% y en BRAF en un 1,6%. No se encontró una relación significativa entre las tasas de mutación y la edad, el sexo y la ubicación del colon de los pacientes. Nuestro estudio demostró que las mutaciones en KRAS, NRAS y BRAF no se asociaron con la edad, el sexo y la localización del tumor de los pacientes con CCR. Los datos presentados son nuestros hallazgos preliminares y se necesita más investigación para evaluar el impacto clínico y patológico de estas mutaciones en la progresión y los resultados del cáncer colorrectal.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[NRAS]]></kwd>
<kwd lng="en"><![CDATA[BRAF]]></kwd>
<kwd lng="en"><![CDATA[KRAS]]></kwd>
<kwd lng="en"><![CDATA[colorectal cancer]]></kwd>
<kwd lng="es"><![CDATA[NRAS]]></kwd>
<kwd lng="es"><![CDATA[BRAF]]></kwd>
<kwd lng="es"><![CDATA[KRAS]]></kwd>
<kwd lng="es"><![CDATA[cáncer colorrectal]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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<volume>9</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>1044-57</page-range></nlm-citation>
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</ref-list>
</back>
</article>
