<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1690-3110</journal-id>
<journal-title><![CDATA[Revista Venezolana de Endocrinología y Metabolismo]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Venez. Endocrinol. Metab.]]></abbrev-journal-title>
<issn>1690-3110</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Venezolana de Endocrinología y Metabolismo]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1690-31102020000300107</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Variabilidad glucémica como parámetro de control metabólico en pacientes con diabetes tipo 1]]></article-title>
<article-title xml:lang="en"><![CDATA[Glycemic variability as parameter of metabolic control in patients with type 1 diabetes]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Villalobos]]></surname>
<given-names><![CDATA[Joalice]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández-Sandoval]]></surname>
<given-names><![CDATA[Gustavo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Paz]]></surname>
<given-names><![CDATA[Jose Javier]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Finol]]></surname>
<given-names><![CDATA[Milexy]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Colina]]></surname>
<given-names><![CDATA[José Luis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Unidad de Diabetes y Enfermedades Metabólicas La Sagrada Familia  ]]></institution>
<addr-line><![CDATA[Maracaibo ]]></addr-line>
<country>Venezuela</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2020</year>
</pub-date>
<volume>18</volume>
<numero>3</numero>
<fpage>107</fpage>
<lpage>120</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_arttext&amp;pid=S1690-31102020000300107&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_abstract&amp;pid=S1690-31102020000300107&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_pdf&amp;pid=S1690-31102020000300107&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN:  Objetivo: Evaluar la variabilidad glucémica según los índices: porcentaje de coeficiente de variación (%CV), promedio de amplitud de excursiones glucémicas (MAGE) y promedio de diferencias diarias (MODD), en un grupo de niños, adolescentes y adultos jóvenes con diabetes tipo 1.  Métodos: Se realizó monitoreo continuo de glucosa (MCG) a 22 pacientes con diabetes tipo 1. Se calcularon los índices %CV, MAGE y MODD. Se utilizaron como puntos de corte, 36% para CV y 60 mg/dl para MODD, diferenciando así a los pacientes con alta o baja variabilidad glucémica. Se compararon las variables demográficas, clínicas y del MCG.  Resultados: El 63,6% de la muestra tuvo un CV &gt;36% con un promedio de edad de 13,7 años, menor promedio de glucemia (157 mg/dl), mayor porcentaje de hipoglucemia (12,9%), más tiempo en rango normal (53,1%), y número de excursiones glucémicas superior, en especial hacia abajo. El valor promedio de MAGE fue 151 mg/ dl, observándose una relación inversa con el número de glucometrías diarias realizadas, siendo de menor tamaño (128,5 mg/dl) en los pacientes usuarios de bomba de insulina. El 63,6% de los pacientes tuvieron un MODD elevado, éstos se diagnosticaron a menor edad y usaron mayor dosis de insulina. No se encontró correlación entre los índices estudiados y la HbA1c.  Conclusión: Los pacientes con mayor variabilidad glucémica tuvieron mayor edad, mayor tiempo en rango, hipoglucemia más frecuente y mayor número de excursiones glucémicas. Los índices CV, MAGE y MODD como indicadores del control metabólico aportan datos de riesgo que son independientes de la HbA1c.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT:  Objective: To assess glycemic variability according to the percentage coefficient of variation (%CV), the average amplitude of glycemic excursions (MAGE), and average daily differences (MODD), in a group of children, adolescents, and young adults with type 1 diabetes.  Methods: Continuous glucose monitoring (CGM) was performed in 22 patients with type 1 diabetes. %CV, MAGE and MODD indices were calculated. The cut-off point for CV was 36% and60mg/dl for MODD, differentiating the patients with high glycemic variability from those with low variability. Comparisons according to demographic, clinical, and CGM tracing variables were made.  Results: The 63.6% of the sample had a CV&gt; 36% with an age average of 13.7 years old, lower average of glycemia, 157 mg/dl, higher percentage of hypoglycemia (12.9%), longer time in normal range (53.1%), and a greater number of glycemic excursions, especially downward. Mean MAGE value was 151 mg/dl, an inverse relationship being observed with the number of daily blood glucose tests performed, being smaller (128.5 mg/dl) in patients using insulin pumps. The 63.6% of the patients had a high MODD, they were diagnosed at a younger age and used a higher dose of insulin. No correlation was found between the studied indices and HbA1c.  Conclusion: Patients with greater glycemic variability were older, had longer time in normal range, more frequent hypoglycemia, and a greater number of glycemic excursions. The CV, MAGE, and MODD indices as indicators of metabolic control provide risk data that are independent of HbA1c.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Variabilidad glucémica]]></kwd>
<kwd lng="es"><![CDATA[diabetes tipo 1]]></kwd>
<kwd lng="es"><![CDATA[coeficiente de variación]]></kwd>
<kwd lng="es"><![CDATA[excursiones glucémicas]]></kwd>
<kwd lng="es"><![CDATA[monitoreo continuo de glucosa]]></kwd>
<kwd lng="es"><![CDATA[MAGE]]></kwd>
<kwd lng="es"><![CDATA[MODD]]></kwd>
<kwd lng="en"><![CDATA[Glycemic variability]]></kwd>
<kwd lng="en"><![CDATA[type 1 diabetes]]></kwd>
<kwd lng="en"><![CDATA[coefficient of variation]]></kwd>
<kwd lng="en"><![CDATA[glycemic excursions]]></kwd>
<kwd lng="en"><![CDATA[continuous glucose monitoring]]></kwd>
<kwd lng="en"><![CDATA[MAGE]]></kwd>
<kwd lng="en"><![CDATA[MODD]]></kwd>
</kwd-group>
</article-meta>
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