<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1690-3110</journal-id>
<journal-title><![CDATA[Revista Venezolana de Endocrinología y Metabolismo]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Venez. Endocrinol. Metab.]]></abbrev-journal-title>
<issn>1690-3110</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Venezolana de Endocrinología y Metabolismo]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1690-31102020000300121</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Dermatitis autoinmune por progesterona]]></article-title>
<article-title xml:lang="en"><![CDATA[Autoimmune progesterone dermatitis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Valencia-West]]></surname>
<given-names><![CDATA[Angela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gericke-Brumm]]></surname>
<given-names><![CDATA[Peter]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyna-Villasmil]]></surname>
<given-names><![CDATA[Eduardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Príncipe de Asturias Servicio de Endocrinología ]]></institution>
<addr-line><![CDATA[Alcalá de Henares ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Príncipe de Asturias Servicio de Anatomía Patológica ]]></institution>
<addr-line><![CDATA[Alcalá de Henares ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Central "Dr. Urquinaona" Departamento de Investigación y Desarrollo ]]></institution>
<addr-line><![CDATA[Maracaibo ]]></addr-line>
<country>Venezuela</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2020</year>
</pub-date>
<volume>18</volume>
<numero>3</numero>
<fpage>121</fpage>
<lpage>126</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_arttext&amp;pid=S1690-31102020000300121&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_abstract&amp;pid=S1690-31102020000300121&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_pdf&amp;pid=S1690-31102020000300121&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN:  Objetivo: Se presenta un caso de dermatitis autoinmune por progesterona.  Caso Clínico: Mujer de 28 años de edad que acudió por presentar erupción eritematosa crónica, pruriginosa desde hace aproximadamente 2 años. La lesión aparecía de forma cíclica justo antes del ciclo menstrual que duraba 3 - 4 días y desaparecía espontáneamente a los 1- 2 días siguientes a la menstruación. El examen físico mostró lesión en forma de placa eritematosa de color uniforme en hombro derecho. La biopsia demostró dermatoepidermitis con hemorragia dérmica intersticial e infiltración de linfocitos perivasculares y presencia de eosinófilos. El análisis de inmunofluorescencia directa de la zona perilesional fue negativo. La prueba de sensibilidad a la progesterona con inyección intradérmica mostró reacción eritematosa local. Los resultados obtenidos fueron considerados como positivos. Todos estos hallazgos permitieron realizar el diagnóstico de dermatitis autoinmune por progesterona. Se indicó tratamiento con agonistas de la hormona liberadora de gonadotropina por 3 meses con mejoría marcada.  Conclusión: La dermatitis autoinmune por progesterona es una afección en la que el ciclo menstrual se asocia con una serie de hallazgos cutáneos como eritema multiforme, eccema, urticaria, angioedema y anafilaxia inducida por progesterona. Estos pueden confundirse frecuentemente con otras formas de dermatosis. Ocurre de 3 a 10 días antes del inicio de la menstruación y desaparece a los 2 días. La patogenia es desconocida. El diagnóstico debe confirmarse por pruebas cutáneas para identificar la respuesta inflamatoria característica. El tratamiento es la inhibición de la secreción de progesterona por supresión de la ovulación.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT:  Objective: A case of autoimmune progesterone dermatitis is presented.  Clinical case: Twenty-eight years old woman who presented with a chronic itchy rash for approximately 2 years. The lesion appeared cyclically just before the menstrual cycle lasting 3-4 days and spontaneously disappeared 1-2 days after menstruation. Physical examination showed an erythematous plaque-like lesion of uniform color on the right shoulder. The biopsy showed dermatoepidermitis with interstitial dermal hemorrhage and infiltration of perivascular lymphocytes and the presence of eosinophils. Direct immunofluorescence analysis of the perilesional area was negative. The progesterone sensitivity test with intradermal injection showed a local erythematous reaction. The results obtained were considered as positive. All these findings allowed the diagnosis of progesterone autoimmune dermatitis to be made. Treatment with gonadotropin-releasing hormone agonists was indicated for 3 months with marked improvement.  Conclusion: Progesterone autoimmune dermatitis is a condition in which the menstrual cycle is associated with a series of skin findings, such as erythema multiforme, eczema, urticaria, angioedema, and progesterone-induced anaphylaxis. These can often be confused with other forms of dermatosis. It occurs 3 to 10 days before the start of menstruation and disappears after 2 days. The pathogenesis is unknown. The diagnosis must be confirmed by skin tests to identify the characteristic inflammatory response. Treatment is inhibition of progesterone secretion by suppression of ovulation.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Dermatitis autoinmune por progesterona]]></kwd>
<kwd lng="es"><![CDATA[progesterona]]></kwd>
<kwd lng="es"><![CDATA[menstruación]]></kwd>
<kwd lng="es"><![CDATA[ciclo menstrual]]></kwd>
<kwd lng="es"><![CDATA[dermatosis]]></kwd>
<kwd lng="en"><![CDATA[Autoimmune progesterone dermatitis]]></kwd>
<kwd lng="en"><![CDATA[progesterone]]></kwd>
<kwd lng="en"><![CDATA[menstruation]]></kwd>
<kwd lng="en"><![CDATA[menstrual cycle]]></kwd>
<kwd lng="en"><![CDATA[dermatosis]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[George]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Badawy]]></surname>
<given-names><![CDATA[SZ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Autoimmune progesterone dermatitis: a case report]]></article-title>
<source><![CDATA[Case Rep Obstet Gynecol]]></source>
<year>2012</year>
<volume>2012</volume>
<page-range>757854</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dedecker]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Graesslin]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Quereux]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Gabriel]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Salmon-Ehr]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Autoimmune progesterone dermatitis: a rare pathology]]></article-title>
<source><![CDATA[Eur J Obstet Gynecol Reprod Biol]]></source>
<year>2005</year>
<volume>123</volume>
<page-range>120-1</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cristaudo]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Bordignon]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Palamara]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[De Rocco]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Pietravalle]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Picardo]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Progesterone sensitive Interferon-gamma producing cells detected by ELISpot assay in autoimmune progesterone dermatitis]]></article-title>
<source><![CDATA[Clin Exp Dermatol]]></source>
<year>2007</year>
<volume>32</volume>
<page-range>439-41</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ljubojevi&#263; Had&#382;avdi&#263;]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Marinovi&#263; Kuli&#353;i&#263;]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Ljubojevi&#263; Grgec]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Poljanac]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Ili&#263;]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Autoimmune progesterone dermatitis diagnosed by lymphocyte transformation test and progesterone provocation test]]></article-title>
<source><![CDATA[Acta Dermatovenerol Croat]]></source>
<year>2018</year>
<volume>26</volume>
<page-range>276-7</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Goossens]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Matura]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Degreef]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Reactions to corticosteroids: some new aspects regarding crosssensitivity]]></article-title>
<source><![CDATA[Cutis]]></source>
<year>2000</year>
<volume>65</volume>
<page-range>43-5</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chang]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Recurrent erythema before menses: autoimmune progesterone dermatitis caused by hypersensitivity to progesterone]]></article-title>
<source><![CDATA[Am J Obstet Gynecol]]></source>
<year>2020</year>
<volume>222</volume>
<page-range>501-2</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Asai]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Katoh]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Nakano]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Wada]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Kishimoto]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Case of autoimmune progesterone dermatitis presenting as fixed drug eruption]]></article-title>
<source><![CDATA[J Dermatol]]></source>
<year>2009</year>
<volume>36</volume>
<page-range>643-5</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Steuer]]></surname>
<given-names><![CDATA[AB]]></given-names>
</name>
<name>
<surname><![CDATA[Scherl]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Ashinoff]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Autoimmune progesterone dermatitis: a diagnosis to consider in a patient with cyclical cutaneous eruptions]]></article-title>
<source><![CDATA[J Drugs Dermatol]]></source>
<year>2017</year>
<volume>16</volume>
<page-range>1040-2</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Varricchi]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Raap]]></surname>
<given-names><![CDATA[U]]></given-names>
</name>
<name>
<surname><![CDATA[Rivellese]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Marone]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Gibbs]]></surname>
<given-names><![CDATA[BF]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Human mast cells and basophils-How are they similar how are they different?]]></article-title>
<source><![CDATA[Immunol Rev]]></source>
<year>2018</year>
<volume>282</volume>
<page-range>8-34</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Abou-Samra]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Selvais]]></surname>
<given-names><![CDATA[CM]]></given-names>
</name>
<name>
<surname><![CDATA[Dubuisson]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Brichard]]></surname>
<given-names><![CDATA[SM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Adiponectin and its mimics on skeletal muscle: Insulin sensitizers, fat burners, exercise mimickers, muscling pills or everything together?]]></article-title>
<source><![CDATA[Int J Mol Sci]]></source>
<year>2020</year>
<volume>21</volume>
<page-range>2620</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Medeiros]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Rodrigues-Alves]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Costa]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Afonso]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Rodrigues]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Cardoso]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Autoimmune progesterone dermatitis: treatment with oophorectomy]]></article-title>
<source><![CDATA[Clin Exp Dermatol]]></source>
<year>2010</year>
<volume>35</volume>
</nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kanninen]]></surname>
<given-names><![CDATA[TT]]></given-names>
</name>
<name>
<surname><![CDATA[Moretti]]></surname>
<given-names><![CDATA[ML]]></given-names>
</name>
<name>
<surname><![CDATA[Lakhi]]></surname>
<given-names><![CDATA[NA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Autoimmune progesterone dermatitis following vaginal progesterone exposure in pregnancy]]></article-title>
<source><![CDATA[Obstet Med]]></source>
<year>2019</year>
<volume>12</volume>
<page-range>100-2</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Detrixhe]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Nikkels]]></surname>
<given-names><![CDATA[AF]]></given-names>
</name>
<name>
<surname><![CDATA[Dezfoulian]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Autoimmune progesterone dermatitis]]></article-title>
<source><![CDATA[Arch Gynecol Obstet]]></source>
<year>2017</year>
<volume>296</volume>
<page-range>1013-4</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stranahan]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Rausch]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Deng]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Gaspari]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The role of intradermal skin testing and patch testing in the diagnosis of autoimmune progesterone dermatitis]]></article-title>
<source><![CDATA[Dermatitis]]></source>
<year>2006</year>
<volume>17</volume>
<page-range>39-42</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rasi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Khatami]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Autoimmune progesterone dermatitis]]></article-title>
<source><![CDATA[Int J Dermatol]]></source>
<year>2004</year>
<volume>43</volume>
<page-range>588-90</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
