<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1690-3110</journal-id>
<journal-title><![CDATA[Revista Venezolana de Endocrinología y Metabolismo]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Venez. Endocrinol. Metab.]]></abbrev-journal-title>
<issn>1690-3110</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Venezolana de Endocrinología y Metabolismo]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1690-31102020000300127</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Linfoma primario de glándula suprarrenal como causa de insuficiencia adrenal]]></article-title>
<article-title xml:lang="en"><![CDATA[Primary adrenal gland lymphoma as a cause of adrenal insufficiency]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Valencia-West]]></surname>
<given-names><![CDATA[Angela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gericke-Brumm]]></surname>
<given-names><![CDATA[Peter]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyna-Villasmil]]></surname>
<given-names><![CDATA[Eduardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Príncipe de Asturias Servicio de Endocrinología ]]></institution>
<addr-line><![CDATA[Alcalá de Henares ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Príncipe de Asturias Servicio de Anatomía Patológica ]]></institution>
<addr-line><![CDATA[Alcalá de Henares ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Central "Dr. Urquinaona" Departamento de Investigación y Desarrollo ]]></institution>
<addr-line><![CDATA[Maracaibo ]]></addr-line>
<country>Venezuela</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2020</year>
</pub-date>
<volume>18</volume>
<numero>3</numero>
<fpage>127</fpage>
<lpage>134</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_arttext&amp;pid=S1690-31102020000300127&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_abstract&amp;pid=S1690-31102020000300127&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_pdf&amp;pid=S1690-31102020000300127&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN:  Objetivo: Reportar un caso de linfoma primario de glándula suprarrenal como causa de insuficiencia adrenal.  Caso Clínico: Se trata de paciente femenina de 62 años quien consultó por presentar pérdida de peso, anorexia, malestar general y sudoración nocturna. Al examen físico hiperpigmentación difusa en piel y mucosa oral y evidencia de hipotensión postural. El abdomen estaba blando, depresible, con dolor a la palpación en ambos flancos y presencia de tumor palpable en ambas regiones lumbares. La ecografía abdominal demostró tumores en ambas glándulas suprarrenales, lo cual fue confirmado por tomografía computada que identificó tumoraciones grandes, heterogéneas y necróticas en ambas glándulas suprarrenales con contornos lobulados, sin evidencia de linfadenopatías retroperitoneales o afección visceral. La tomografía por emisión de positrones mostró captación intensa de fluorodeoxiglucosa en ambas glándulas suprarrenales. Las pruebas de laboratorio demostraron el diagnóstico de insuficiencia suprarrenal con prueba de estimulación negativa. La biopsia de la glándula suprarrenal izquierda confirmó el diagnóstico de linfoma primario. La paciente inició la quimioterapia y tratamiento de sustitución con hidrocortisona.  Conclusión: Los linfomas extra-ganglionares pueden aparecer en cualquier órgano. El linfoma primario de la glándula suprarrenal es un tipo muy raro de linfoma extra-ganglionar. La presentación clínica es inespecífica y puede incluir dolor abdominal, pérdida de peso, fiebre, anemia, náuseas y vómitos. Frecuentemente puede manifestarse como tumores suprarrenales bilaterales y la insuficiencia suprarrenal es una complicación común. Debe considerarse en el diagnóstico diferencial de las tumoraciones suprarrenales bilaterales, especialmente si el paciente presenta insuficiencia suprarrenal. El pronóstico es malo.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT:  Objective: To report a case of primary adrenal gland lymphoma as a cause of adrenal insufficiency.  Clinical case: A 62-year-old female patient who consulted for presenting weight loss, anorexia, malaise and night sweats. On physical examination, diffuse hyperpigmentation of the skin and oral mucosa and evidence of postural hypotension. The abdomen was soft, depressible, with pain on palpation on both flanks and the presence of a palpable tumor in both lumbar regions. Abdominal ultrasound showed tumors in both adrenal glands, which were confirmed by computed tomography that identified large, heterogeneous, and necrotic tumors in both adrenal glands with lobed contours, with no evidence of retroperitoneal lymphadenopathy or visceral involvement. Positron emission tomography showed intense uptake of fluorodeoxyglucose in both adrenal glands. Laboratory tests demonstrated the diagnosis of adrenal insufficiency with a negative stimulation test. Biopsy of the left adrenal gland confirmed the diagnosis of primary lymphoma. Patient started chemotherapy and hydrocortisone replacement treatment.  Conclusion: Extra-ganglionic lymphomas can appear in any organ. Primary lymphoma of the adrenal gland is a very rare type of extranodal lymphoma. The clinical presentation is nonspecific and may include abdominal pain, weight loss, fever, anemia, nausea, and vomiting. It can often manifest as bilateral adrenal tumors, and adrenal insufficiency is a common complication. It should be considered in the differential diagnosis of bilateral adrenal tumors, especially if the patient has adrenal insufficiency. The prognosis is bad.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Linfoma primario de glándula suprarrenal]]></kwd>
<kwd lng="es"><![CDATA[linfoma]]></kwd>
<kwd lng="es"><![CDATA[glándula suprarrenal]]></kwd>
<kwd lng="es"><![CDATA[insuficiencia suprarrenal]]></kwd>
<kwd lng="en"><![CDATA[Primary adrenal gland lymphoma]]></kwd>
<kwd lng="en"><![CDATA[lymphoma]]></kwd>
<kwd lng="en"><![CDATA[adrenal gland]]></kwd>
<kwd lng="en"><![CDATA[suprarrenal insufficiency]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[DY]]></given-names>
</name>
<name>
<surname><![CDATA[Kang]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Jung]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Park]]></surname>
<given-names><![CDATA[YM]]></given-names>
</name>
<name>
<surname><![CDATA[Cho]]></surname>
<given-names><![CDATA[JG]]></given-names>
</name>
<name>
<surname><![CDATA[Baek]]></surname>
<given-names><![CDATA[SK]]></given-names>
</name>
<name>
<surname><![CDATA[Kwon]]></surname>
<given-names><![CDATA[SY]]></given-names>
</name>
<name>
<surname><![CDATA[Jung]]></surname>
<given-names><![CDATA[KY]]></given-names>
</name>
<name>
<surname><![CDATA[Woo]]></surname>
<given-names><![CDATA[JS]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Extranodal involvement of diffuse large B-cell lymphoma in the head and neck: An indicator of good prognosis]]></article-title>
<source><![CDATA[Auris Nasus Larynx]]></source>
<year>2019</year>
<volume>46</volume>
<page-range>114-21</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ram]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Rashid]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Farooq]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Ulhaq]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Islam]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Primary adrenal non-Hodgkin lymphoma: a case report and review of the literature]]></article-title>
<source><![CDATA[J Med Case Rep]]></source>
<year>2017</year>
<volume>11</volume>
<page-range>108</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Erçolak]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Kara]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Günald&#305;]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Usul Af&#351;ar]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Bozkurt Duman]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Aç&#305;kal&#305;n]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Ergin]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Erdo&#287;an]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Bilateral primary adrenal non-hodgkin lymphoma]]></article-title>
<source><![CDATA[Turk J Haematol]]></source>
<year>2014</year>
<volume>31</volume>
<page-range>205-6</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cambiaso]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Bottaro]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Cianfarani]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Tomà]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Vito]]></surname>
<given-names><![CDATA[RD]]></given-names>
</name>
<name>
<surname><![CDATA[Cappa]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[An incidental finding of bilateral adrenal lymphoma]]></article-title>
<source><![CDATA[Am J Med Sci]]></source>
<year>2016</year>
<volume>352</volume>
<page-range>80</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Khurana]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Kaur]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Chauhan]]></surname>
<given-names><![CDATA[AK]]></given-names>
</name>
<name>
<surname><![CDATA[Kataria]]></surname>
<given-names><![CDATA[SP]]></given-names>
</name>
<name>
<surname><![CDATA[Bansal]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Primary Non Hodgkin's Lymphoma of left adrenal gland - a rare presentation]]></article-title>
<source><![CDATA[J Clin Diagn Res]]></source>
<year>2015</year>
<volume>9</volume>
<page-range>XD01-3</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Herndon]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Nadeau]]></surname>
<given-names><![CDATA[AM]]></given-names>
</name>
<name>
<surname><![CDATA[Davidge-Pitts]]></surname>
<given-names><![CDATA[CJ]]></given-names>
</name>
<name>
<surname><![CDATA[Young]]></surname>
<given-names><![CDATA[WF]]></given-names>
</name>
<name>
<surname><![CDATA[Bancos]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Primary adrenal insufficiency due to bilateral infiltrative disease]]></article-title>
<source><![CDATA[Endocrine]]></source>
<year>2018</year>
<volume>62</volume>
<page-range>721-8</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Raoofziaee]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Yarmohamadi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Ahmadnia]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Primary bilateral non-Hodgkin's lymphoma of the adrenal gland]]></article-title>
<source><![CDATA[Indian J Urol]]></source>
<year>2018</year>
<volume>34</volume>
<page-range>300-2</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Padhi]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Sahoo]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Primary adrenal non Hodgkin lymphoma: changing trends]]></article-title>
<source><![CDATA[Turk J Gastroenterol]]></source>
<year>2015</year>
<volume>26</volume>
<page-range>85-6</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Malik]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Chapman]]></surname>
<given-names><![CDATA[CB]]></given-names>
</name>
<name>
<surname><![CDATA[Drew]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A case of primary adrenal diffuse large B-cell lymphoma in HIV]]></article-title>
<source><![CDATA[Int J STD AIDS]]></source>
<year>2016</year>
<volume>27</volume>
<page-range>687-9</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Karimi]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Primary adrenal lymphoma presenting with adrenal failure: a case report and review of the literature]]></article-title>
<source><![CDATA[Int J Endocrinol Metab]]></source>
<year>2017</year>
<volume>15</volume>
</nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Simpson]]></surname>
<given-names><![CDATA[WG]]></given-names>
</name>
<name>
<surname><![CDATA[Babbar]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Payne]]></surname>
<given-names><![CDATA[LF]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Bilateral primary adrenal non-Hodgkin's lymphoma without adrenal insufficiency]]></article-title>
<source><![CDATA[Urol Ann]]></source>
<year>2015</year>
<volume>7</volume>
<page-range>259-61</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Spyroglou]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Schneider]]></surname>
<given-names><![CDATA[HJ]]></given-names>
</name>
<name>
<surname><![CDATA[Mussack]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Reincke]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[von Werder]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Beuschlein]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Primary adrenal lymphoma: 3 case reports with different outcomes]]></article-title>
<source><![CDATA[Exp Clin Endocrinol Diabetes]]></source>
<year>2011</year>
<volume>119</volume>
<page-range>208-13</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[De Miguel Sánchez]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Ruiz]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
<name>
<surname><![CDATA[Hernández]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Acute adrenal insufficiency secondary to bilateral adrenal B-cell lymphoma: a case report and review of the literature]]></article-title>
<source><![CDATA[Ecancermedicalscience]]></source>
<year>2016</year>
<volume>10</volume>
<page-range>634</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aziz]]></surname>
<given-names><![CDATA[SA]]></given-names>
</name>
<name>
<surname><![CDATA[Laway]]></surname>
<given-names><![CDATA[BA]]></given-names>
</name>
<name>
<surname><![CDATA[Rangreze]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Lone]]></surname>
<given-names><![CDATA[MI]]></given-names>
</name>
<name>
<surname><![CDATA[Ahmad]]></surname>
<given-names><![CDATA[SN]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Primary adrenal lymphoma: Differential involvement with varying adrenal function]]></article-title>
<source><![CDATA[Indian J Endocrinol Metab]]></source>
<year>2011</year>
<volume>15</volume>
<page-range>220-3</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Babinska]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Peksa]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Sworczak]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Primary malignant lymphoma combined with clinically "silent" pheochromocytoma in the same adrenal gland]]></article-title>
<source><![CDATA[World J Surg Oncol]]></source>
<year>2015</year>
<volume>13</volume>
<page-range>289</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
