<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0535-5133</journal-id>
<journal-title><![CDATA[Investigación Clínica]]></journal-title>
<abbrev-journal-title><![CDATA[Invest. clín]]></abbrev-journal-title>
<issn>0535-5133</issn>
<publisher>
<publisher-name><![CDATA[Instituto de Investigaciones Clínicas "Dr. Américo Negrette", Facultad de Medicina, Universidad del Zulia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0535-51332024000100005</article-id>
<article-id pub-id-type="doi">10.54817/ic.v65n1a01</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Clinical effects of Cook® cervical ripening balloon on promoting cervical dilation for early termination of pregnancy in high-risk parturients.]]></article-title>
<article-title xml:lang="es"><![CDATA[Efectos clínicos del balón de maduración cervical de Cook® sobre la dilatación cervical para la interrupción temprana del embarazo en las parturientas de riesgo alto.]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Han]]></surname>
<given-names><![CDATA[Xiaorui]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cai]]></surname>
<given-names><![CDATA[Junnan]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Dong]]></surname>
<given-names><![CDATA[Wei]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[Ya]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Xingtai People&#8217;s Hospital Department of Gynecology and Obstetrics ]]></institution>
<addr-line><![CDATA[Xingtai ]]></addr-line>
<country>China</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2024</year>
</pub-date>
<volume>65</volume>
<numero>1</numero>
<fpage>5</fpage>
<lpage>15</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_arttext&amp;pid=S0535-51332024000100005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_abstract&amp;pid=S0535-51332024000100005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_pdf&amp;pid=S0535-51332024000100005&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract We aimed to evaluate the clinical effects of oxytocin, misoprostol, controlled-release dinoprostone suppository, and Cook® cervical ripening balloon on early termination of pregnancy in high-risk parturients. Four hundred high-risk full-term parturients not in labor who were unsuitable for awaiting delivery and treated from May 2018 to July 2020 were divided into groups I-IV with a random number table (n=100). They received labor induction by oxytocin, misoprostol, controlled-release dinoprostone suppository, and Cook® cervical ripening balloon, respectively. The general data, cervical ripening effect, delivery outcome, delivery time, adverse reactions, and neonatal conditions were compared. The time from the beginning of labor induction to labor and duration of the first, third, and total stages of labor were shorter in group II-IV than in group I (p&lt;0.05). The incidence rates of excessive uterine contraction in groups II and III were higher than those of groups I and IV, and the incidence rates of fetal distress in groups I-III exceeded that of group IV (p&lt;0.05). The neonatal Apgar scores of groups III and IV were higher than those of groups I and II (p&lt;0.05). Cook® cervical ripening can promote cervical maturation and shorten the labor induction time and stage of labor.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Nuestro objetivo fue evaluar los efectos clínicos de la oxitocina, el misoprostol, el supositorio de dinoprostona de liberación controlada y el balón de maduración cervical de Cook® en la interrupción temprana del embarazo en parturientas de alto riesgo. Cuatrocientas parturientas a término de alto riesgo que no estaban en trabajo de parto y que no estaban aptas para esperar el parto y fueron tratadas desde mayo de 2018 hasta julio de 2020 se dividieron en grupos I-IV con una tabla de números aleatorios (n = 100). Recibieron inducción del trabajo de parto con oxitocina, misoprostol, supositorio de dinoprostona de liberación controlada y balón de maduración cervical de Cook®, respectivamente. Se compararon los datos generales, efecto de maduración cervical, resultado del parto, tiempo de parto, reacciones adversas y condiciones neonatales. El tiempo desde el inicio de la inducción del trabajo de parto hasta el parto y la duración de la primera etapa, tercera etapa y etapa total del trabajo de parto fueron más cortos en el grupo II-IV que en el grupo I (p&lt;0,05). Las tasas de incidencia de contracción uterina excesiva en el grupo II y III fueron más altas que las del grupo I y IV, y las tasas de incidencia de sufrimiento fetal en el grupo I-III excedieron las del grupo IV (p&lt;0,05). Las puntuaciones de Apgar neonatal del grupo III y IV fueron más altas que las del grupo I y II (p&lt;0,05). El globo de maduración cervical de Cook® puede promover la maduración cervical, acortar el tiempo de inducción del parto y las etapas del parto.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Cook® cervical ripening balloon]]></kwd>
<kwd lng="en"><![CDATA[cervical dilation]]></kwd>
<kwd lng="en"><![CDATA[high-risk parturient]]></kwd>
<kwd lng="en"><![CDATA[termination of pregnancy]]></kwd>
<kwd lng="es"><![CDATA[balón de dilatación cervical COOK]]></kwd>
<kwd lng="es"><![CDATA[maduracion cervical]]></kwd>
<kwd lng="es"><![CDATA[parturientas de alto riesgo]]></kwd>
<kwd lng="es"><![CDATA[interrupción del embarazo]]></kwd>
</kwd-group>
</article-meta>
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