<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0535-5133</journal-id>
<journal-title><![CDATA[Investigación Clínica]]></journal-title>
<abbrev-journal-title><![CDATA[Invest. clín]]></abbrev-journal-title>
<issn>0535-5133</issn>
<publisher>
<publisher-name><![CDATA[Instituto de Investigaciones Clínicas "Dr. Américo Negrette", Facultad de Medicina, Universidad del Zulia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0535-51332025000200217</article-id>
<article-id pub-id-type="doi">10.54817/ic.v66n2a08</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Impact of regional anesthesia vs general anesthesia on postoperative outcomes in elderly patients with hip fracture: a meta-analysis.]]></article-title>
<article-title xml:lang="es"><![CDATA[Impacto de la anestesia regional vs anestesia general en los resultados posoperatorios en pacientes ancianos con fractura de cadera: un meta-análisis.]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Han]]></surname>
<given-names><![CDATA[Feng]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[Yue]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Tian]]></surname>
<given-names><![CDATA[Xinxin]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hangzhou Geriatric Hospital Department of Anesthesiology ]]></institution>
<addr-line><![CDATA[Hangzhou ]]></addr-line>
<country>China</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hangzhou Ninth People&#8217;s Hospital Department of Infectious Diseases ]]></institution>
<addr-line><![CDATA[Hangzhou ]]></addr-line>
<country>China</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<volume>66</volume>
<numero>2</numero>
<fpage>217</fpage>
<lpage>230</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_arttext&amp;pid=S0535-51332025000200217&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_abstract&amp;pid=S0535-51332025000200217&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://ve.scielo.org/scielo.php?script=sci_pdf&amp;pid=S0535-51332025000200217&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The objective of this study was to utilize meta-analysis to compare the impact of regional anesthesia (RA) versus general anesthesia (GA) on postoperative outcomes in elderly patients undergoing hip fracture surgery. Electronic databases (PubMed, Web of Science, Cochrane Library, and Embase) were searched for randomized controlled trials (RCTs) comparing the effects of RA and GA in elderly patients undergoing hip fracture surgery. The random or fixed-effects model was used to calculate pooled relative risks (RR) and mean differences (MD). Fourteen RCTs involving 5626 elderly patients undergoing hip fracture surgery were included. Meta-analysis indicated that RA was associated with a lower incidence of intraoperative blood loss (MD: -39.7 mL; 95% CI: -68.61, -10.84; p = 0.007), adverse events including intraoperative hypotension (RR: 1.09; 95% CI: 0.90, 1.32; p = 0.005) and postoperative cognitive dysfunction (RR: 0.56; 95% CI: 0.37, 0.86; p = 0.007) compared to GA. However, no statistically significant differences were found between RA and GA regarding surgical time, anesthesia time, intraoperative transfusion, hospital length, delirium, and mortality. RA can effectively reduce intraoperative blood loss and the risk of hypotension. Due to the current lack of evidence, no positive effects of RA on other postoperative outcomes were identified. A rigorously designed, high-quality study is warranted to determine the impact of anesthesia type on elderly hip fracture patients.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El objetivo de este estudio fue utilizar meta-análisis para comparar el impacto de la anestesia regional (AR) versus la anestesia general (AG) en los resultados posoperatorios en pacientes ancianos sometidos a cirugía de fractura de cadera. Se buscó en las bases de datos electrónicas (PubMed, Web of Science, Cochrane Library y Embase) ensayos controlados aleatorios (ECA) que compararan los efectos de AR vs AG en pacientes de edad avanzada sometidos a cirugía de fractura de cadera. Se utilizó el modelo de efectos aleatorios o fijos para calcular los riesgos relativos agrupados (RR) y las diferencias de medias (DM). Se incluyeron 14 ECA con 5.626 pacientes de edad avanzada sometidos a cirugía de fractura de cadera. El metanálisis indicó que la AR se asoció con una menor incidencia de pérdida de sangre intraoperativa (DM: -39,7 mL; IC 95%: -68,61, -10,84; p = 0,007), eventos adversos incluyendo hipotensión intraoperativa (RR: 1,09; IC del 95%: 0,90, 1,32; p = 0,005) y disfunción cognitiva posoperatoria (RR: 0,56; IC 95% : 0,37, 0,86; p = 0,007) comparado con GA. Sin embargo, no se encontraron diferencias estadísticamente significativas entre AR y AG en términos de tiempo quirúrgico, tiempo de anestesia, transfusión intraoperativa, duración hospital, delirio y mortalidad. La AR puede reducir eficazmente la pérdida de sangre intraoperatoria y el riesgo de hipotensión. Debido a la actual falta de pruebas, no se identificaron efectos positivos de la AR en otros resultados posoperatorios. Se justifica un estudio de alta calidad y rigurosamente diseñado para determinar el impacto del tipo de anestesia en pacientes ancianos con fractura de cadera.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[hip fracture]]></kwd>
<kwd lng="en"><![CDATA[anesthesia]]></kwd>
<kwd lng="en"><![CDATA[elderly]]></kwd>
<kwd lng="en"><![CDATA[meta-analysis]]></kwd>
<kwd lng="es"><![CDATA[fractura de cadera]]></kwd>
<kwd lng="es"><![CDATA[anestesia]]></kwd>
<kwd lng="es"><![CDATA[ancianos]]></kwd>
<kwd lng="es"><![CDATA[meta-análisis]]></kwd>
</kwd-group>
</article-meta>
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