Resumen

RIVERA, Zulay et al. Exosomes in skin: Therapeutic potential. Rev. Digit. Postgr. [online]. 2025, vol.14, n.3, e433.  Epub 30-Ene-2026. ISSN 2244-761X.  https://doi.org/10.37910/rdp.2025.14.3.e433.

Abstract: Considering the key roles that exosomes play in skin physiology, this paper explores their potential application as therapeutic and cosmetic agents for tissue regeneration, regulation of inflammation, and the deceleration of skin aging. This review aims to present the main sources of exosomes and their use in skin therapies and cosmetics. The primary sources include epidermal progenitor stem cells (EPSC), dermal papilla cell-derived exosomes (DPC-Exos), and mesenchymal stem cells (MSC), particularly from adipose tissue (AD-MSCs). EPSC-derived exosomes have been shown to enhance diabetic wound healing by regulating TGFβ signaling and influencing fibroblast and macrophage behavior. DPC-Exos play a role in hair follicle cycles. MSC-derived exosomes promote re-epithelialization, reduce inflammation, stimulate collagen and elastin secretion, and activate protective pathways like SIRT1/Nrf2. In cosmetics, exosomes are used in topical formulations (creams, serums, masks) for skin hydration, protection, and collagen stimulation. Clinical studies confirm that exosomes help improve skin elasticity, hydration, and texture, while reducing scars and pigmentation disorders. Additionally, exosomes are explored for skin rejuvenation and pigmentation control, thanks to their ability to modulate melanogenesis pathways. Overall, exosomes derived from various stem cell types hold great promise for therapeutic and cosmetic applications, offering innovative solutions for wound healing, anti-aging, pigmentation issues, and hair growth.

Palabras clave : Exosomes; Skin Diseases; Wound; Capillary; Macrophages; Fibroblasts.

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