Abstract

ROJAS-SANCHEZ, Fátima; LALAGUNA, Fernando; INFANTE, Yanira  and  ACEVEDO, Ana Maria. Efecto inhibitorio del nonanoato de potasio y el fluoruro de sodio en la acidogenicidad de la placa dental humana in vitro : Nonanoato de Potasio y Fluoruros como inhibidores de la placa dental. Acta odontol. venez [online]. 2000, vol.38, n.2, pp.27-32. ISSN 0001-6365.

Nonanoic acid a saturated 9-carbon fatty acid, was earlier shown to reduce fissure caries in rats when included in their diet (Hayes and Berkovitz, 1979).  Griffiths in 1979 showed that potassium nonanoate added to sugar-rinses inhibits plaque bacteria in man.  The aim of this study was to evaluate the effect of potassium nonanoate (NK), sodium fluoride (NAF) and their combination on acid production, and this was assessed by back tritation using the method described by Hayes and Roberts, (1980).  At pH 7.4 KN and NaF added separately reduced acid production by 45.0% and 54.5%, respectively, compared to the control.  The reduction in acid production when using the compounds in combination was 39%.  At pH 5.5, both KN and NaF alone showed 21.2% and 29.3% inhibition, respectively, and when combined this inhibition increased to 49.3%.  At pH 5.5 a cumulative effect of KN and NaF was observed.  We conclude that at acid pH both compounds, KN+NaF combined would be the best to be effective.

Keywords : Potassium nonanoate; Fatty acids; Sodium Fluoride; Metabolism.