Resumen

ORELLANA, Alejandra  y  SALAZAR, Esmeralda. Evaluación clínica de la terapia con dexametasona e ibuprofeno en la cirugía de los terceros molares retenidos. Acta odontol. venez [online]. 2007, vol.45, n.1, pp.54-60. ISSN 0001-6365.

The surgical removal of impacted third molar teeth can result in considerable pain, swelling and dysfunction. The factors contributed to postoperative pain, edema and trismus are complex, but many of the contributors factors are related to the inflammatory process. Pharmacologic strategies for minimizing the clinical manifestation of surgical trauma are often directed toward blocking the acute inflammation. Corticosteroids have been suggested for the reduction of inflammatory sequel of surgical procedures, including the removal of third molar teeth. Others authors recommend the combination of this drug with some NSAIDs like Ibuprofen.Objetives: the purpose of this double-blind study was to evaluate and to compare a prototype glucocorticoid, dexamethasone in combination with Ibuprofen and placebo for suppression of swelling due to the surgical removal of the third molar and determinate their real toxicity. METHODS: thirty patients, including 9 males and 21 females aged between 15 and 35 years old, randomly divided in two groups: one of the group received 8 mg dexamethasone (Decalona®) and the other group received placebo, one our prior to each procedure, either dexamethasone or placebo was administered intramuscularly. Both groups received 400 mg ibuprofen (Brugesic®) each 6 hours for two days and 500 mg amoxiciline (Trimoxal®) each 8 ours for 7 days. The effect of treatment was evaluated using three methods: subjectively, anatomical references measurements, and digital photos by computerized method.. Pain was evaluated by Analog Visual Scale. Results: This investigation revealed a higher efficacy of the therapy with dexamehtasone e ibuprofen than ibuprofen alone to edema postoperative control. Our results demonstrated no statically significant differences with regard to pain. We also no observed  postoperative infection neither adverse effect with this therapy in the evaluated patients.