Abstract

IBARRA, Gumy C et al. Alteraciones ultraestructurales en la microvasculatura de la región de la cara en pacientes VIH.. Acta odontol. venez [online]. 2007, vol.45, n.2, pp.178-181. ISSN 0001-6365.

Ultrastructural alterations of squeletic muscle fibers in HIV+ patients have been described. In orbicular muscle fibers of lips were realized the following observations: atrophy, sarcotubular system desorganization and hyperchromatic nuclei. Changes found in the microvasculature were similar to there seen in autoimmune disorders as Systemic Lupus Erythematosus, Autoimmune Diabetes and Sjörgen Syndrome. Propose: evaluation of microvascular ultrastructural alterations in orbicular muscles in HIV patients. Material and Methods: biopsies were taken from lips orbicular muscles in patients attending the Centre for the Care of Patients with Infections and Contagions diseases “Dra Elsa La Corte” between years 2001 and 2002, females and males, with ages between 38 and 53 years. Patients used HAART therapy, present myopathy. .Biopsies were processed according to rutinary techniques for Transmission Electron Microscopy. Results: proliferative endothelial cell cytoplasm in some case rupture of plasma membrane with necrosis, widening of basement membrane, endothelial cell cytoplasm with different electron densities and infolding of cytoplasm into the lumen. Conclusion: it is suggested that the effects of HIV on the skeletal muscle microvasculature are similar to those described in other autoimmune diseases.

Keywords : microvascular; orbicular muscle fiber; ultrastructural alterations; HIV.