Abstract

ARREAZA, A; CORRENTI, M; PERRONE, M  and  AVILA, Mayra. Evaluación de las Moléculas de Fibrinógeno, del Complemento C3, C4, C1q,  y Anticuerpos IgG, IgM e IgA  por Inmunofluorescencia directa, en pacientes con Liquen Plano Bucal.. Acta odontol. venez [online]. 2008, vol.46, n.1, pp.29-35. ISSN 0001-6365.

Lichen planus is a chronic inflammatory mucocutaneous disease that frequently involves the oral mucosa. The aim of this study was the evaluation of fibrinogen, C1q, C3, C4, IgG, IgM, IgA  by direct immunofluorescense in patients with oral lichen planus (OLP). We evaluated 20 patients with OLP and 10 patients withouth lesions. We used direct immunofluorescense with policlonals antibodies to fibrinogen, C1q C3, C4, IgM , IgG e IgA. (Dako Corporation, Conpenhagen, Denmark) Conpenhagen, Our results demonstrated that all the samples were positive for fibrinogen. Aditionally 16/20 (80%) of the patients were positive for IgG, 12/20 (60%) for IgM and only one patient was positive for IgA. Regarding complement, 14/20 samples (70%) were positives for C3, 8/20 (37.5%), for C1q, while 4/20 (20%) demonstrated positivity for C4. We may suggest that the  complement immunoexpresion could be posible for the presence of  an exogen antigen that stimulate the immune response in lesions of OLP.

Keywords : Oral Lichen planus; direct immunofluorescense; Complement, IgG; IgA; IgM.