Abstract

GUTIERREZ, R; CORRENTI, M; PERRONE, M  and  DE GUGLIELMO, Z. Determinación de Subpoblaciones linfocitarias en lesiones de pacientes con Estomatitis Aftosa Recurrente. Acta odontol. venez [online]. 2008, vol.46, n.2, pp.144-150. ISSN 0001-6365.

Recurrent aphtous stomatitis (RAS) is one of the most common oral mucosal diseases known. It presents as threee types: minor (most prevalent), major and herpetiform. However, not thue well established its etiology although, many evidences indicated that the patients affected with this condition have a defectous celular immune response. The objective of this study was the determination of  the lymphocytes subpopulations T CD4+ and T CD8+ in patients with RAS. We evaluated 19 patients, 15  with minor RAS and 4 with major RAS.  As a control group we included 10 patients withouth RAS.  We obtained a biopsy of each patient, that was procesed by immunohistochemistry. We observed a very high amount of lymphocytes subpopulations in the patients with RAS in comparation with the control group. The results suggested the association  of the T lymphocytes and the the celular immune response in the pathogenesis of the RAS

Keywords : Estomatitis Aftosa Recurrente; Inmunidad celular.