Abstract

LUNA, M et al. Detección de arn de virus hepatitis c en la saliva de un grupo de pacientes con hepatitis c crónica. Acta odontol. venez [online]. 2008, vol.46, n.3, pp.269-272. ISSN 0001-6365.

Hepatitis C is a worldwide public health problem and its transmisión is clearly associated with the parenteral route, however, the virus has also been isolated from other body fluids, including saliva, although the relationship between HCV and oral pathology is not clearly understood. The aim of this study was to determine the presence of HCV-RNA in saliva from patients with chronic C hepatitis. In the present investigation 24 patients, attended at the Hepatology Department, at the the Clinical Hospital University, Central University of Venezuela, with HCV infection were evaluated . 5ml of unstimulated saliva were taken of each patient. Saliva HCV-RNA was detected by Polymerase Chain Reaction (PCR). 29% (7/24) of HCV+ patients showed HCV-RNA in saliva. In this study, we observed the presence of HCV-RNA in saliva of patients infected with HCV. Further large-scale epidemiological studies are required to clarify the clinical significance of HCV in the saliva, including the potencial for viral transmisión through exposure to these fluids.

Keywords : Saliva; HCV virus; Reverse Transcription Polymerase Chain Reaction (RT-PCR).