Resumen

LOPEZ, Guadalupe  y  GALVAN, Marcos. Relation of total cholesterol in serum tocopherols. ALAN [online]. 2011, vol.61, n.2, pp.127-134. ISSN 0004-0622.

Epidemiological studies have shown the effect of nutritional status of tocopherols and development of cardiovascular diseases that now are more frequent during early years of life. In this work we evaluated the association between the total cholesterol and serum levels of tocopherols in a population of Mexican children in whom we measured the oxidant status and antioxidant capacity (December 2003). In 1155 children (12-59 months) residents of urban and rural locations we quantified in serum a-tocopherol, γ-tocopherol and total cholesterol; the antioxidant capacity and oxidative status were evaluated with the production of TBARS. Children with serum cholesterol > 240 mg/dL cholesterol recorded an average of 577.3 ± 200.8 μg/dL. However, when tocopherols were expressed in relation to total cholesterol (μmol/mmol) found that children with > 240 mg/dL of cholesterol in whom the relationship was low (1.93 ± 0.69). There were no differences in serum antioxidant capacity, but if in the production of TBARS for children with > 200 mg/dL cholesterol. In preschools the increases in total cholesterol limits the availability of serum tocopherol for circulating lipids, this condition over time could determine the early development of vascular injury mediated by oxidative stress.

Palabras clave : Alpha tocopherol; gamma tocopherol; cholesterol; antioxidant capacity; TBARS.