Resumen

VIVEROS-VALDEZ, Ezequiel et al. Antioxidant, cytotoxic and alpha-glucosidase inhibition activities from the Mexican berry “Anacahuita” (Cordia boissieri). ALAN [online]. 2016, vol.66, n.3, pp.211-218. ISSN 0004-0622.

This study describes the total phenolic and flavonoid content as well as cytotoxic, alpha-glucosidase inhibition and antiradical/antioxidant potential of extracts obtained from the edible fruits of Cordia boissieri, which is widely distributed throughout northeastern Mexico. Phenolic and flavonoid content were evaluated by means of the Folin-Ciocalteu method and aluminum chloride colorimetric assay respectively. The antiradical/antioxidant activity was determined by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging and Trolox Equivalent Antioxidant Capacity (TEAC) assays. Cytotoxic activity was assessed by means of human cancer cell lines (MCF-7 and HeLa), alpha-glucosidase inhibition was determined by colorimetric assay using p-Nitrophenyl α-D-glucopyranoside (PNPG) as a substrate. Results indicate that extract of C. boissieri fruit has a good antioxidant potential to show a EC₅₀: 137.76 ± 35 μg/mL and 65 ± 2 μM/g in the DPPH and TEAC assays respectively, inhibitor of the enzyme alpha-glucosidase involved in sugar uptake (IC₅₀: 215.20 ± 35 μg/mL), cytotoxic activities against MCF-7 (IC₅₀: 310 ± 42 μg/mL) and HeLa (IC₅₀: 450.4 ± 21 μg/mL) cancer cell lines as well as an important phenolic content with 230 ± 23 mg/100g and 54± 11 mg/100g of phenols and flavonoids totals respectively. These results point towards an interesting potential for the fruits of C. boissieri as chemopreventive properties and expand the possibilities for agro-industrial uses.

Palabras clave : Fruits; antioxidants; alpha-glucosidase; chemopreventive.

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