Abstract

MONTBRUN, Miryan; GUTIERREZ, Marlén; CIOCCIA, Anna M.  and  HEVIA, Patricio. La diarrea inducida con lactosa es más severa, prolongada y produce mayores pérdidas fecales de macronutrientes en ratas cecotomizadas que en ratas intactas. ALAN [online]. 2017, vol.67, n.1, pp.32-41. ISSN 0004-0622.

Lactose induced diarrhea is more severe, last longer and produces more fecal macronutrient losses in cecectomized than in intact rats.. Lactose induced diarrhea in rats has been used for studying the appropriated feeding during diarrhea. However, rats adapt to lactose and this diarrhea last approximately one week. In order to establish if cecum removal could prolong it, here lactose induced diarrhea was produced in intact and cecectomized rats. In the experiment there were 16 intact and 16 cecectomized rats. Halve of the rats in each group were fed a diet with 45% lactose (Diarrhea group) and the other halve a lactose free diet (Control group). The experiment lasted 21 days and included three 48h fecal collections (days 2-4, 9-11 and 17-19). The results showed that during the first collection both groups had diarrheas of similar severity but thereafter, only the cecectomized had a diarrhea whose severity increased (3.5 times) with time. Additionally, in both groups of rats, protein and fat fecal losses were proportional to fecal output but they were higher (2 times) in the cecectomized group. In conclusion, cecectomy prevents lactose adaptation and results in a diarrhea that last longer and it is more severe (3.5 times). Also in these rats fecal losses of macronutrients are higher whereas feed efficiency is lower.

Keywords : Diarrhea; lactose; rats; intact; cecectomized; severity; fecal losses; protein; fat.

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