Resumen

MILBRATZ DE CAMARGO, Anice; HENRIQUEBONDE, Débora Delwing Dal Magro; DELWING DE LIMA, Daniela  y  COUTINHO DE AZEVEDO CAMPANELLA, Luciane. COCOA AND CLASSICAL MUSIC: EFFECT ON ANXIETY AND ANTIOXIDANT ACTIVITY IN WISTAR RATS . ALAN [online]. 2017, vol.67, n.2, pp.106-115. ISSN 0004-0622.

The effect of cocoa powder and subchronic exposure to classical music in Wistar rats behavior on an xiety evaluation tests and their antioxidant activity was evaluated. The animals were divided into four groups: control group (CG), cocoa powder group (CPG), music group (MG) and cocoa powder with music group (CPMG). During 15 days, CPG and CPMG received commercial non alkalized cocoa powder daily (66 mg total polyphenols / g of product, by oral gavage), while MG and CPMG were exposed to the music of Mozart (Serenade N.10 in B flat major for woodwinds and bass, "Gran partita" K.361 / 370a, Largo movement, 8:35 mi nutes long). At the end of the experiment, the animals were submitted to elevated plus maze (EPM) and open field (OF) tests, and serum analysis of thiobarbituric acid reactive substances index (TBA RS) and the activity of antioxidant enzymes catalase (CAT), superoxide dismu tase (SOD) and glutathione peroxidase (GSH Px). Ani mals from MG and CPMG groups showed the highest total horizontal locomotion and more time spent at the central area and reduced immobility time at the OF. The TBA RS average of the treated groups were lower than the GC. The average activity of CAT was higher in CPMG than the others, and the average activity of SOD and GSH Px were higher only in CPG and CPMG. We concluded that the treatment with this classical music sho wed mild anxiolytic activity. Both treatments (cocoa and music) improved serum antioxidant status, but the peri pheral activity of different serum enzymes was mainly improved by the cocoa powder.

Palabras clave : Cocoa powder; classical music; anxiety; elevated plus maze; open field; oxidative stress.