Resumo

VILLARROEL, Montserrat Vicente et al. Citocinas TH2 (IL 4 e IL10) en el niño desnutrido: Universidad del Zulia, Maracaibo - Venezuela. Arch Venez Puer Ped [online]. 2008, vol.71, n.2, pp.42-47. ISSN 0004-0649.

Objective: To determine the cytokine serum measurements Th2 (IL4 and IL10), in malnourished children and eutrophic without infection, in ages understood between 6 months and 6 years. Method: 89 children were selected; 64 children with some grade of malnourishment (mild, moderate and severe) and 25 eutrophic children. The cytokines was measured in outlying blood using ELISA'S double sandwich method. For the statistical analysis we use the test of ANOVA with post test of Tukey. Results: They are presented like Mean + SD. The IL4 showed in the group of malnourished, higher levels: mild (0.46±0.04 pg/ml), moderate (0.48±0.10pg/ml) and severe (0.55±0.006pg/ml), presenting each group significant differences (p <0.001) in relation with the control group (0.37±0.004 pg/ml). There were also significant differences among the groups of mild malnourished and moderate with the severe ones p <0.001. The IL10 showed significant differences among the moderate malnourished (9.91±3.17 pg/ml) and the severe (10.88±5.13 pg/ml) with the control group (6.53± 2.59pg/ml) (p <0.01). Conclusion: The high values of IL4 and IL10 in the malnourished children are consequence of damage in the capacity of activation of the immune cells in the same ones, being added the grade of parasitic infection with worms that present that conditions the rise of IL4.

Palavras-chave : Malnourished; Cytokines Th2; IL 4; IL 10.