Resumen

RAMIREZ SANCHEZ, Manuel Segundo; PASCUZZO LIMA, Carmine  y  BASTIDAS, Omaira. Tratamiento de intoxicaciones por compuestos hepatotóxicos: Uso de la N-acetilcisteina y las Carboximetilcisteina. Arch Venez Puer Ped [online]. 2009, vol.72, n.2, pp.68-72. ISSN 0004-0649.

N-acetylcysteine (NAC) is a drug with antidotal properties useful in poisoning by hepatotoxic compounds such as paraquat, acetaminophen and inorganic phosphorus. Although the frequency and severity of this type of poisoning are significant, NAC is not readily available in Venezuela. Certain pharmacokinetic and pharmacodynamic characteristics of NAC and S-carboxymetylcisteine (SCMC), available in venezuelan pharmaceutical market are discussed. In addition, a review of the clinical and experimental experiences with SCMC in poisoning for hepatotoxic compounds is presented.

Palabras clave : Poisoning; Hepatotoxicity; N-Acetylcysteine; S-Carboxymetylcisteine.