Resumen

VELASQUEZ, Gleida et al. Glomerulonefritis rapidamente progresiva en el niño. Análisis de la casuistica de un quinquenio 2004-2009. Arch Venez Puer Ped [online]. 2010, vol.73, n.1, pp.006-009. ISSN 0004-0649.

Rapidly progressive glomerulonephritis (RPGN) is a rare entity; early diagnosis is important for adequate and prompt treatment. The objective of this paper is to report the casuistic of RPGN in the Department of Nephrology of the Hospital de Niños “Jorge Lizarraga” between January 2004 and January 2009. Method: Retrospective and descriptive study collecting data of the medical records of 8 patients, ages 3-13 years. Results: Six patients were females and the average for age was 11±3.5 years. The majority presented a previous infection (skin in 6 and pharynx in 1). Clinical manifestations and laboratory findings were: edema, hypertension, hematuria, progressive azotemic retention, proteinuria and hypocomplementemia. Renal biopsy was performed in all patients with the following results: endo and extracapillary proliferative glomerulonephritis in 6 cases and membranoproliferative glomerulonephritis in 2. Therapeutic measures were aimed to the treatment of infection acute renal failure. Methylprednisolone boluses were indicated in all patients, 6 patients were submitted to peritoneal dialysis. Six patients survived (2 with normal renal function and 4 with progression to chronic kidney disease), and 2 died. Conclusions: RPGN is a condition that occurs sporadically; its evolution depends of the severity of renal involvement, the extension of histological lesions and the precocity with which pharmacological and dialytic treatment are installed. Most patients survive but a significant number progress to chronic kidney disease.

Palabras clave : Glomerulonephritis; renal insufficiency; renal biopsy.