Resumen

HERNANDEZ HERNANDEZ, Naibelin Josefina; USECHE MEDINA, Nilcia Daniela  y  MACIAS-TOMEI, Coromoto. Skeletal maturity and nutritional status in children and adolescents with nephrotic syndrome. Arch Venez Puer Ped [online]. 2012, vol.75, n.2, pp.45-51. ISSN 0004-0649.

Introduction: Glucocorticoids, commonly used in the treatment of nephrotic syndrome could interfere in children’s growth and development. Skeletal maturity determined by Tanner-Whitehouse II method (TW2) constitutes an indicator of bone maturation. Objective: To analyze the behavior of bone age (BA) related to anthropometric nutritional status and to clinical and pathological characteristics of children and adolescents with nephrotic syndrome. Methods: This is a cross-sectional, exploratory, descriptive and correlational study. Twenty eight patients (11 girls, 17 boys) diagnosed with nephrotic syndrome that attended the nephrology outpatient clinic of the Pediatric Hospital Dr. Elías Toro, from August to October 2008. Weight and height were measured using international techniques, and a left hand and wrist X-ray was evaluated by the TW2-method. ANOVA, t-Student test and Pearson correlation coefficient were calculated with a significance level of p< 0.05. Results: boys predominated (60.7%). Body mass index was above normal in 2 patients and normal in the rest. BA was normal in 24 children (85.7%), advanced in three (10.7%) and delayed in one. An inverse relationship was found between the number of relapses and the percentage of maturity reached in steroid resistant male patients (p < 0.05). Conclusion: This study shows a probable difference in the behavior of BA, according to gender steroid resistance.

Palabras clave : skeletal maturity; nephrotic syndrome; corticosteroids; children and adolescents.

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