Abstract

PAEZ, Rosela et al. Determinación de la fibrosis y cirrosis hepática a través de un simple índice no invasivo en pacientes con hepatitis crónica por virus c. Gen [online]. 2006, vol.60, n.2, pp.83-86. ISSN 0016-3503.

Objetive: to use APRI index for predicting significant hepatic fibrosis and cirrosis in patients with chronic hepatitis C infection.Patients and methods: a retrospective study was done with 54 patients who chronic hepatitis infection, the diagnosis was established by the presence of hepatitis C virus RNA, biochemical and liver biopsy parameters. Results: of 54 patients, 57% were female, the mean age was 41,7 years old. Mild fibrosis (F1) was more frequent with 28% in women. APRI index in our study had a sensitivity of 52% and specificity of 17%, positive predictive value of 54% and negative predictive value of 15% for significative fibrosis and a sensitivity of 29%, specificity of 17%, positive predictive value of 33% and negative predictive value of 14% for cirrosis. Conclusion: APRI index was more sensitivity for predicting fibrosis but with a low specificity whereas for cirrosis was less.

Keywords : Fibrosis; Cirrosis; APRI index; Chronic hepatitis; Virus C.

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