Resumo

APARCERO, Miguel et al. Tumor estromal gastrointestinal del intestino delgado con expresión negativa del marcador oncogénico KIT (CD117): A propósito de un caso. Gen [online]. 2006, vol.60, n.3, pp.210-214. ISSN 0016-3503.

Gastrointestinal stromal tumors (GIST) are uncommon but important mesenchymal tumors of the Gastrointestinal Tract, defined as being of mesodermal origin. Macroscopically they present as intramural submucosal masses, being the most common mesenchymal tumors to arise from the gastrointestinal tract. The malignant form, typically aggressive and resistant to treatment, in fortunately rare. An important development has been the characterization of the oncogene marker KIT, and its relation to the pathogenesis of GIST. However recent research has shed light on the genesis of GIST that is KIT negative. KIT is highly sensitive for GIST (though not 100%) but is not a marker of malignancy or essential requirement to the diagnosis of GIST. We show a patient with a GIST of the small intestine, KIT- negative.

Palavras-chave : Mesenchymal tumors; stromal tumors of the gastrointestinal tract (GIST); submucosal tumors of the gastrointestinal tract.

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