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vol.61 issue2Rendimiento diagnóstico de la cápsula endoscópica y enteroscopia doble balón en pacientes con hemorragia digestiva oscuraIntroduction and Aims: Combined treatment with pegylated interferon and lamivudine can constitute a suitable alternative in order to obtain seroconversion in pediatric patients with virus B chronic infection. The aim of the present study was to evaluate the response of pediatric patients with chronic virus B infection given by the lost of Age VHB and DNA VHB, and the appearance of antibodies against Age VHB and normalization of aminotranferases in patients treated with pegylated interferon alpha 2a in combination with lamivudine. Patients and Methods: Pediatric patients with chronic infection by virus B were included, with positive HBe Ag, anti- HBe Ab-, HBV DNA positive, elevation of aminotranferases for more than 6 months These patients received treatment with pegylated interferon alpha 2a and lamivudine 4 mgs/kg/day for 52 weeks. Results: The transmission routes were vertical in 2 patients, transfusional in 7and 1 unknown. PatientÊs mean age was 10,3+ 3,47 years, with an average time of exposure to virus B of 5,2+3,93 years. The average of aminotranferases at the beginning of treatment was AST 112,3+46,3 and ALT 127,8 + 44. Twelve weeks following treatment AST levels were 33,3+12,14 and ALT 35,5+ 13,51.The histological findings were: 2 patients had moderate inflammatory activity, 8 mild activity , 2 developed moderate fibrosis and 8 mild fibrosis. Only 1 patient developed anemia and leucopenia that did not require the suspension of treatment. Ten (10) patients (100%) developed fever, 8 (80%) migraine during the 4 first weeks of treatment; they remained asymptomatic during the 48 remaining weeks. The 10 patients had normal aminotranferases at 12 weeks following treatment. Two (2) (20%) of the patients presented loss of Ags VHB and Ac positive Ags VHB 12 weeks post treatment. Of 10 patients 4 (40%) had seroconversion (Age VHB, negative DNA VHB and Ab positive Age VHB) by week 52 of treatment and 12 weeks post treatment. Conclusion: Combined treatment with pegylated interferon and lamivudine constitute an effective and safe therapeutic option for pediatric patients with chronic infection by virus B. author indexsubject indexarticles search 		Home Pagealphabetic serial listing  

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Print version ISSN 0016-3503On-line version ISSN 2477-975X

Abstract

LANDAETA, J et al. Cápsula endoscópica y enteroscopia doble balón en pacientes con patología del intestino delgado. Gen [online]. 2007, vol.61, n.2, pp.100-104. ISSN 0016-3503.

Introducción: La cápsula endoscópica (CE) y la enteroscopia de doble balón (EDB) fueron introducidas como nuevas modalidades endoscópicas para el estudio del intestino delgado. Objetivo: comparar el rendimiento diagnóstico de estos dos métodos en la evaluación de pacientes con patología del intestino delgado. Pacientes y métodos: estudio descriptivo de una muestra de 97 pacientes de ambos géneros mayores de 12 años, que acudieron al Servicio de Gastroenterología del Hospital Vargas de Caracas y Policlínica Metropolitana entre diciembre 2004 y mayo 2006, con indicación médica para evaluación del intestino delgado por cápsula endoscópica y/o enteroscopia doble balón. Resultados: a 30 pacientes se les realizó CE (12 mujeres, 18 hombres) edad promedio 58,95 años. Se encontraron hallazgos positivos en 72,41%. A 67 pacientes (36 mujeres, 31 hombres) se les realizó enteroscopia doble balón, edad promedio de 52,9 años. Hubo hallazgos positivos en 62,68%. Hubo 3 complicaciones menores (4,4%) tratadas médicamente. Conclusión: el rendimiento diagnóstico de la CE y EDB fue similar para detectar lesiones del intestino delgado. EDB permite realizar toma de biopsias y procedimientos terapéuticos.

Keywords : cápsula endoscópica; enteroscopia de doble balón; intestino delgado.

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