Abstract

LANDAETA, N et al. Polimorfismo HLA-DQ en pacientes pediátricos con enfermedad Celíaca. Gen [online]. 2008, vol.62, n.2, pp.92-95. ISSN 0016-3503.

The celiac disease is an enteropathy characterized by malabsortion and epitelial damage of the small bowel, of the one which cells specific T has been isolated to gluten and restricted to the DQ2-DQ8 heterodímers, suggesting that the DQ alelles play a key role in the pathogenesis of the disease for the presentation of derived péptides from the gluten to T linfocites. In our study we evaluate the HLA-DQA and DQB polymorphism in pediatric patients with celiac Disease. 16 patients were studied from Gastroenterology service of the "Hospital de Niños JM de los Ríos". The polymorphism was defined through PCR-sequence; the assignments of alleles and haplotype were determined by direct count. Similar to other reports which suggest HLA DQ2 y DQ8 as markers in genetic predisposition in celiac disease, this study is the first in Venezuela in screened HLA in Celiac Disease.

Keywords : Celiac disease; HLA; and polymorphism.