Abstract

JANET MARIA, Rendón V et al. Expresión del receptor del factor de crecimiento epidérmico en carcinoma gástrico: Relación clínico patológica. Gen [online]. 2009, vol.63, n.3, pp.158-162. ISSN 0016-3503.

Gastric carcinoma is still one of the most common cancer types worldwide, with a significant mortality rate. The study of its oncogenesis has identified several molecular and genetic factors that play an important role in its evolution, including the receptor for epidermal growth factor (CSFR). This cross-sectional descriptive study was aimed to analyze the expression of this receptor in 36 gastrectomy specimens collected in the „Dr. Antonio María Pineda‰ Central University Hospital from 2002 to 2006, using the labeled streptavidin-biotin method of immunohistochemical analysis, and establishing the correlation between its expression and different clinical-pathological parameters of recognized prognostic value. A higher frequency of EGFR expression was found in cases with minor tumoral extension in gastric wall (T1- T2 = 58.33%), in invasions to lymphatic ganglia (65.2%; p = 0.15) and distant organs (75%; p = 0.53), and in cases of advanced stage (IV=75%) and disease (III- IV= 66.67%; p = 0.36) and those with moderate grade of differentiation (66.67%). Statistical analysis showed that there was no correlation between these outcomes. EGFR is related to gastric carcinoma progression and might have a predictive role in the advanced disease.

Keywords : Gastric Carcinoma; Epidermal Growth Factor Receptor; Immunohistochemical Clinical-Pathological Correlation.