Abstract

MARQUEZ, Lucia; SALAS, Albermary; MOSCHELLA, Filomena  and  ARTIS, María Teresa. Seroprotección contra el virus de hepatitis b en pacientes pediátricos con cáncer. Gen [online]. 2010, vol.64, n.4, pp.341-343. ISSN 0016-3503.

Introduction: Patients with cancer are a population in risk of being infected by Hepatitis B virus as a consequence of being exposed to methods favoring the parenteral inoculation of the virus. Purpose: Quantifying the antibodies against the surface antigen for Hepatitis B virus in patients without protection titers when admitted to the pediatric hematology-oncology service and who received a short vaccination schedule (0, 1, and 2 months). Patients and Methods: Between March 2008 and 2009, 40 patients were received, from which later on 17 were excluded from the study since 8 showed infection positive markers for Hepatitis B, and 9 with values higher than 100IU/L. 16 patients without protection titers were recombinant- vaccinated. Serologies for Hepatitis B were determined: Surface Antigen, Antibody against surface antigen, and anticore every 3 months during 1 year, being considered as the antibody protectors against the surface antigen higher than 100IU/L. Results: Out of the 16 patients (100%) who were vaccinated: 15 (94%) reached protection titers, showing antibody decrease against surface antigen in the study term. Conclusion: Vaccinated patients reached seroprotection with later progressive diminishing of protection titers, thus justifying revaccination.

Keywords : Hepatitis B; vaccines; children; cancer.