Abstract

ORTIZ M, Magda  and  ESCALANTE, Nancy. Hepatitis c y diabetes mellitus tipo 2: un estudio prospectivo. Gen [online]. 2011, vol.65, n.1, pp.42-45. ISSN 0016-3503.

An epidemiologic link between chronic Hepatitis C (HCV) and Type 2 Diabetes mellitus (DM) has been established. The objective of the present study was to prospectively determine the prevalence of Diabetes Mellitus (DM) and impaired fasting glucose (IFG) in patients with hepatitis C not treated or naive, in comparison with the general population and patients with other hepatic diseases. A sample of 13 patients who went to the outpatient clinic of the Zuliana Foundation of the Liver, from January of year 2008 to December of year 2009 was included in the study. The prevalence of DM and IGA was of 38% compared with 8% of the general Population (Center Venezuelan of information and statistic) and 25% of the group control of 16 patients with other hepatic diseases. Of 13 patients five were Genotype 1b, one genotype 1a and seven Genotype 2a. Of the patients with DM or IGA, two were Genotype 1b, one 1a and two 2a. Of the five patients with DM or IGA four had family history of Diabetes. In conclusion, patients with chronic HCV have a greater prevalence of DM and IGA in comparison with the general population and patients affected by different hepatics diseases. There was not relation in this study between the Genotype with the DM or the IGA; the anthropomorphic markers of Obesity were associated in three of the five patients, which added to the familiar history of Diabetes will follow a multifactorial relation in the pathogenesis of the DM in the patients with HCV.

Keywords : Chronic Hepatitis C; Diabetes Mellitus type 2; Impaired fasting glucose.