Abstract

SILVA, Rossy et al. Urea breath test and histopathological features related to helicobacter pylori infection. Gen [online]. 2012, vol.66, n.2, pp.93-99. ISSN 0016-3503.

Introduction: There are many methods to diagnose H. pylori infection. It is proposed to compare the cuantitative14C Urea Breath Test with the histopathological features in the antrum related to H. pylori in the population of Mucuchíes. Materials and Methods: 108 patients between 18 and 75 years were included to perform the 14C Urea Breath Test, and the upper digestive endoscopy with four biopsy samples obtained from the gastric antrum. The sensitivity, specificity, PPV, NPV and Kappa index were determined for the 14C Urea Breath Test, and correlations between the 14C Urea Breath Test and histological features were determined too. Results: We obtained 74 copositive patients, with a sensitivity of 87,05% and specificity of 73,91% for the 14C UBT. The PPV was of 92,5% and the NPV was of 60,71%. The Kappa index was of 0,56. A linear correlation between the test and the histological features was found. Conclusions: The 14C UBT is a very useful tool in the diagnosis of H. pylori infection and its related histopathological features.

Keywords : Urea Breath Test; H. pylori; Histopathological features.