Abstract

CANONICCO, Maryraida et al. Hepatitis B vaccination in children with celiac disease, inmunological response. Gen [online]. 2012, vol.66, n.2, pp.114-117. ISSN 0016-3503.

Aim: To determine the immune response to the vaccination against hepatitis B virus in pediatric patients with celiac disease. Patients and methods: Reviewed 25 medical histories of celiac diagnosed between 2001-2010 by serological, histopathological, genetic studies and full hepatitis B vaccination scheme, of which 11 patients were excluded. Also ask antibody against hepatitis B virus surface antigen The group of non-responder celiac was evaluated after revaccination under attachment to diet without gluten. Results: 14 Patients were studied (35.7% females, 64.3% boys). 8 patients vaccinated at birth and 6 after eight years of age. Of which 28.6% had low response to vaccination and 71.4% unanswered. The answer was positive in 3/8 (37.5%) of patients vaccinated at birth and 1/6 of the 8 older (16.7%). not answering. 4 were fulfilling gluten-free diet, showing response immunological positive in 75%. Conclusion: There is a decrease in the response to vaccination against hepatitis B in celiac patients, conditional primarily by HLA DQ2 and that the gluten-free diet can improve the immune response.

Keywords : Disease celiac; vaccine hepatitis B; HLA.