Abstract

QUIROGA, Claudia et al. Aminotransferases elevation and its relationship with hepatic steatosis in obese patients. Gen [online]. 2013, vol.67, n.2, pp.87-90. ISSN 0016-3503.

NAFLD is the leading cause of chronic liver disease being the most common cause of altered transaminases in up to 66 to 90%. Objetive: Determine the elevation of aminotransferases and its relationship to hepatic steatosis in obese. Patients and Methods: We performed a descriptive, prospective and transversal study; the sample used was intentional, non-probability from January to April 2012. We included 45 obese persons aged 18 to 70 years old; we performed to all an abdominal ultrasound and blood chemistry. Results: Of the 45 patients included 73.3% (n = 33) were female, mean age was 47 ± 14 years, mean BMI was 33.4 ± 5.5, the mean concentration of SAST was 41 ± 15 IU/mL and SALT was 34 ± 14 IU/mL. The mean total cholesterol concentration was 201 ± 39 mg and triglycerides 171 ± 82 mg. Conclusions: patients with hepatic steatosis had elevation of AST compared to patients without steatosis, (p = 0.071), the value of ALT was higher in patients with steatosis than in patients without steatosis, (p = 0.004), we can infer that hepatic steatosis influences their elevation. As for total cholesterol and triglycerides, no relationship was found, although total cholesterol was higher in the group of patients with steatosis than in patients without steatosis. Association was found between the degree of obesity and the presence of hepatic steatosis (p = 0.001).

Keywords : NAFLD; hepatic steatosis; obesity; hypertransaminasemia.

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