Abstract

NAVARRO, Dianora et al. Oral tolerance development in children with allergy to cow's milk protein: Follow-up of 10 years. Gen [online]. 2013, vol.67, n.3, pp.127-132. ISSN 0016-3503.

It is estimated that allergic children develop oral tolerance in the early years of life with a dairy elimination diet. Objective: To determine the time development of oral tolerance to cow's milk protein, clinical and laboratory. Patients and Methods: A prospective study followed for 10 years, children allergic to cow's milk protein. He said elimination diet for 4 weeks after challenge. Was requested total IgE and specific. Age and time was recorded to confirm diet tolerance. Results: 81 children, 33/81 (40.74%) were female and 48/81 (59.25%) male, average age at diagnosis 6.22 months (range <1-42). IgE-mediated allergy is not 32/81 (39.50%) and IgE-mediated allergy 49/81 (60.49%) specific IgE to cow's milk positive in 55/81 (67.90%). Diagnosis by positive response to the elimination diet in 62/81 (76.54%) and challenge in 19/81 (23.45%). Tolerance developed after 12-18m with diet, 21/32 (65.62%) with non-IgE allergy to 1.6 years and 23/49 (46.93%) with IgE allergy to 2.13 years. The remaining children tolerated between 19-24m, to the 2.35 and 2.80 years for non-IgE allergy and IgE, respectively. After 36m, continued without tolerating 5 children between the two groups with multiple food allergy progress. Conclusions: The diagnosis of allergy can be based on positive response to milk elimination diet, the challenge is necessary in uncertain cases and tolerance is reached at an earlier age in children with IgE mediated allergy is not.

Keywords : oral tolerance; IgE mediated allergy; no IgE-mediated; food allergy; cow's milk.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )