Abstract

PERAZA, Simón et al. Recommendations of the Venezuelan experts for immunohistochemical determination of HER2 in gastric cancer. Gen [online]. 2013, vol.67, n.4, pp.208-215. ISSN 0016-3503.

Introduction: HER2 oncogene amplification in gastric adenocarcinoma was described in 1986, predominantly in the intestinal type. The identification of advanced gastric carcinomas with HER2 abnormalities is essential in daily clinical practice, as these neoplasms require specific treatment election Afterward publication Toga trial on HER2 expression in advanced gastric cancer and the Union gastroesophageal is necessary in our country the determination of this alteration. Methods: In this section we establish the methodological requirements for the study of HER2 and permits the use of appropriate therapy. The methods consists of a Pre analytical phase and an analytical phase itself, in this regard the role of gastroenterologists and surgeons in making samples and handling of surgical specimens is definitely crucial. Conclusions: The aim of this agreement is to teach gastroenterologists, surgeons, medical oncologists and pathologists the importance of handling specimens and surgical endoscopic biopsies, according to strict standards that allow reliable studies. Moreover, there is instruction on the proper interpretation of immunohistochemical studies on endoscopic biopsy, endoscopic mucosal resection and surgical specimens by pathologists.

Keywords : Gastric cancer; HER2 immunohistochemistry.

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