Abstract

FOX, Clara  ; LIZARZABAL, Maribel; PRADO, Zahira  and  MENGUAL, Edgardo. Hepatobiliopancreatic cancer frequency and its relationship to diabetes mellitus in patients of the hospital universitario de Maracaibo. Gen [online]. 2014, vol.68, n.3, pp.94-98. ISSN 0016-3503.

Diabetes mellitus has been associated with the presence of some types of cancer of the digestive tract, especially in recent years has been linked to cancer of the liver, pancreas and bile ducts. That is why we undertook the present retrospective study in order to determine the frequency of hepatobiliopancreatic cancer and its association with the presence of diabetes in patients at Maracaibo University Hospital during the period 2006-2012. 97 cases were reported, with a diagnosis of primary hepatic malignancies (hepatocellular carcinoma, intrahepatic cholangiocarcinoma) 26.8% 21.6% distal extrahepatic cholangiocarcinoma, Klatskin tumor 16.5% 10.3% pancreatic cancer, tumor periampullar 5,2% and gallbladder tumor 5.2%. In diabetic patients, the most common tumors were pancreatic cancer and primary hepatic malignancies (94.8%, p<0,01). It was not observed in the rest of the patients significant association between cancer diagnosis and the presence of diabetes. Prospective studies are needed in order to establish the factors that may influence the genesis of cancer in diabetic patients, such as the type of treatment, metabolic and inflammatory factors that may be involved.

Keywords : Liver cancer; pancreatic cancer; biliary tract cancer; Diabetes mellitus; indicators of systemic inflammation.

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