Abstract

GONZALEZ, Juan Carlos. Prevención de la Diverticulitis Aguda Recurrente on Bacillus clausii. Gen [online]. 2015, vol.69, n.1, pp.2-6. ISSN 0016-3503.

Diverticular Disease (DD), or Diverticulitis, is one of the most common gastrointestinal diseases affecting the general population in the western world; approximately 20% of patients are symptomatic and 75% suffer from painful DD: acute diverticulitis, 25-33% of those patients may suffer from recurrent episodes. Changes in colon microbiota cause chronic inflammation and epithelial cell proliferation developed in colon mucosa and around the diverticula. Prebiotics restore colon’s microenvironment, from where the treatment of patients with asymptomatic DD is proposed, in order to avoid the Acute Diverticulitis. The study aimed to investigate the proportion of patients who maintained the referral after a previous episode of uncomplicated Acute Diverticulitis, when treated with Bacillus clausii: two billions every eight hour during one year. Materials and Methods: Prospective and retrospective study, with non-probabilistic, intentional-type sampling and control arm. Arm A: Fifty patients diagnosed with uncomplicated Acute Diverticulitis, were administered with a single treatment of Bacillus clausii, two billions, every eight hours during one year. Clinical controls every three months. Arm B (control): 50 untreated patients diagnosed with uncomplicated Acute Diverticulitis. Outcomes: The necessary information to carry out the R variance analysis was introduced; a significant difference was found between the study’s arm averages; a F(1,48)=5.259,  p<0.05 was found. Conclusion: because of its biological characteristics, Bacillus clausii prevents Diverticular Disease’s inflammatory complications such as the Recurrent Acute Diverticulitis.

Keywords : Recurrent Acute Diverticulitis; Diverticular Disease; Diverticulitis; Probiotic. Bacillusclausii.

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