Abstract

DEVERA, Rodolfo et al. USE OF NITAZOXANIDE IN THE TREATMENT OF CHILDREN INFECTED WITH GIARDIA LAMBLIA. Gen [online]. 2015, vol.69, n.1, pp.7-12. ISSN 0016-3503.

Introduction: Nitazoxanide is a new drug that has shown to be helpful against various intestinal protozoa including Giar­dia lamblia. However, there are few studies on the subject at national and regional scopes. A study was conducted to test the therapeutic utility of nitazoxanide in children infected with G. lamblia, citizens of Ciudad Bolívar, Bolívar state. Pa­tients and methods: Were diagnosed and selected 21 cases of children parasitized G. lamblia and they were treated with nitazoxanide, then 3 post-treatment controls at 7, 15 and 21 days using the methods of direct parasitological examina­tion, Kato and spontaneous sedimentation were performed. Results: The overall percentage of parasitological cure was 37.5 % (6/16) consisting of 6 children in whom posttreatment parasite was eradicated. From this analysis, 5 of the 21 trea­ted children were excluded because they did not attended one or more post- treatment controls. None of the children who received treatment with nitazoxanide presented adverse effects. Conclusion: In the group studied, and due to their low percentage of parasitological cure, nitazoxanide not ap­pear to be the drug of choice and should be reserved for use in cases of therapeutic failure or when there is intolerance to metronidazole.

Keywords : Giardia lamblia; treatment; nitazoxanide; chil­dren.

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