Resumo

ROMERO, Gisela  e  MENDEZ DE FEBRES, Jessika. Coagulopatia en enfermedad hepática severa. Intervención de factores anticoagulantes, pro­coagulantes y fibrinoliticos. Gen [online]. 2015, vol.69, n.1, pp.17-21. ISSN 0016-3503.

The liver is an organ that is involved in the synthesis of procoa­gulant factors, anticoagulates and fibrinolytic, which depends on the balance sheet in blood clotting. In patients with cirrhosis of the liver is lost this balance by disorders of the metabolism of these factors, as well same, failures occur in the function of hepatic synthesis, dysfunction of the endothelium state due to the LV hyperdynamic in cirrhosis and significant alterations in both the number and the function of platelets.   For these reasons the patients with advanced liver disea­se/cirrhosis, may have episodes of bleeding from mucosa, or to other tissues or thromboembolic events in the deep venous system, pulmonar or portal vein thrombosis. To treat coagulo­pathy in patients with liver disease requires careful interpreta­tion of pathophysiology and a clear therapeutic intervention.

Palavras-chave : Hepatic cirrhosis; coagulopathy; thromboembolism.

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