Abstract

SANCHEZ IRIARTE, Nairé Milagros; SOLES DABOIN, Rossy Chiquinquirá  and  RODRIGUEZ DE MARQUEZ, María Luisa. HYPERDYNAMIC CIRCULATION IN CIRRHOTIC PATIENTS: RENAL EXPRESSION OF EFFECTS OF PROPRANOLOL . Gen [online]. 2015, vol.69, n.4, pp.115-124. ISSN 2477-975X.

Introduction: To investigate the potential damage to the kidney function that can cause non-selective beta blocker drugs (BBNS) in cirrhotic patients with decompensated extreme hemodynamic balance its effects were evaluated by administering to patients with cirrhosis and ascites, with varying degrees of decompensation. Methods: We performed a prospective analysis of twenty patients, ten with cirrhosis and ascites and ten with spontaneous bacterial peritonitis. A control group of ten subjects was studied too. All groups underwent measurement of blood pressure, and blood and urine tests, pre and post treatment with propranolol. Results: Significant difference (p<0.04) was observed in urinary sodium between total patients without treatment and control group. The Rate of Sodium Reabsorption was significant between compensated patients and those with SBP, (p<0.04) before treatment. Patients without SBP pre and post treatment showed also, however, there was no significant difference between patients with SPB although there was a tendency to decrease sodium excretion. Low Mean arterial pressure, factor of poor prognosis in these patients showed positive correlation with low urinary sodium excretion in Child C patients with SBP post treatment. Conclusions: Patients with liver and extensive degree of hemodynamic decompensation are susceptible of renal impairment.

Keywords : cirrhosis; ascites; hyperdynamic circulation; propranolol, sodium.

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